This pattern appears to be similar to the glycine-tryptophan repeat bodies (GWB) antibody that is found in mitochondrial negative patients. The patient harbouring this antibody is a 39 year old male with a history of hepatitis C infection, who developed a cancerous lump and required liver transplant.
This patient had raised polyclonal immunoglobulins and multiple dot ANA (liver associated) with a titre of 1/100 but LKM, smooth muscle and mitochondrial negative.
Large dot in some nuclei
Large dot in some nuclei (probably mitotic related).
The appearance of this antibody is similar to cytoplasmic rings/rods pattern observed in some patients with HCV viral infection.