During autoantibody screening, there may be a possilibity of encountering a rare or unusual reaction of sera on the tissue which may be of no clinical significance. Here, we share some examples that you may be familiar with.
Liver: Bile Canaliculus antibodies
Rodent liver showing staining of the walls of the canaliculi. The clinical role of this antibody remains unclear
Kidney: Antibodies to tubule brush border
Brushborder membrane antibody staining the microvilli of the proximal kidney tubules. Microvilli are not present on the lumen of distal tubules hence most of the medulla is negative.
Higher magnification of the tubules. The clinical significance of this antibody in undetermined.
A reaction of the serum autoantibodies against basal cell layer (see below).
Epithelial basal cell layer antibodies
Primate oesophagus epithelium: Basal cell layer antibodies. This antibody does not appear to have any clinical significance.