Clinical Trials

Translational research within the Clinical Immunology Service

Haematolymphoid malignancy

Papers - Phase 3 trials in multiple myeloma

Mead GP, Carr-Smith HD, Drayson MT, Morgan GJ, Child JA, Bradwell AR. (2004) Serum free light chains for monitoring multiple myeloma. Br J Haematol. Aug;126(3):348-54.

Child JA, Morgan GJ, Davies FE, Owen RG, Bell SE, Hawkins K, Brown J, Drayson MT, Selby PJ; Medical Research Council Adult Leukaemia Working Party. (2003) High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med. May 8;348(19):1875-83.

Bradwell AR, Carr-Smith HD, Mead GP, Harvey TC, Drayson MT (2003) Serum test for assessing patients with Bence Jones Myeloma Lancet 8;361: 489-91

Mead GP, Drayson MT, Carr-Smith HD, Bradwell AR. (2003) Measurement of immunoglobulin free light chains in serum. Clin Chem. 2003 Nov;49(11):1957-8

The International Myeloma Working Group (2003) Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 121(5):749-757

Mead GP, Carr-Smith HD, Drayson MT, Bradwell AR (2003) Detection of Bence Jones myeloma and monitoring of myeloma chemotherapy using immunoassays specific for free immunoglobulin light chains. Clin Lab 49:25-7

Rawstron AC, Davies FE, DasGupta R, Ashcroft AJ, Patmore R, Drayson MT, Owen RG, Jack AS, Child JA, Morgan GJ. (2002) Flow cytometric disease monitoring in multiple myeloma: the relationship between normal and neoplastic plasma cells predicts outcome after transplantation. Blood. 2002 Nov 1;100(9):3095-100.

Bradwell AR, Carr-Smith HD, Mead GP, Drayson MT (2002) Serum free light chain immunoassays and their clinical application. Clinical and Applied Immunology Reviews 3: 17 - 33

Drayson, M., Tang, L.X., Drew, R., Mead, G.P., Carr-Smith, H., Bradwell A.R. (2001) Serum free light chain measurements for identifying and monitoring patients with nonsecretory multiple myeloma. Blood 97 (9) :2900-2

Bradwell, A.R., Carr-Smith, H.D., Mead, G.P., Tang, L.X., Showell, P.J., Drayson, M.T., Drew, R. (2001) Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine. Clinical Chemistry 47(4):673-80

McCloskey, E.V., Dunn, J.A., Kanis, J.A., MacLennan, I.C.M., Drayson, M.T. (2001) Long-term follow-up of a prospective, double-blind, placebo-controlled randomised trial of clodronate in multiple myeloma. British Journal Haematology 113 (4) 1035-1043

The UK Myeloma Forum Guidelines Working Group (2001). Guidelines on the diagnosis and management of multiple myeloma. Br J Haematol 115;3:522-40

Graziani MS, Merlini G, Bradwell AR, Drayson MT, Mead GP (2001) Measurement of free light chains in urine. Clinical Chemistry 47 (11) 2069-2070

Davies FE, Forsyth PD, Rawstron AC, Owen RG, Pratt G, Evans PA, Richards SJ, Drayson M, Smith GM, Selby PJ, Child JA, Morgan GJ (2001) The impact of attaining a minimal disease state after high-dose melphalan and autologous transplantation for multiple myeloma. British Journal Haematology 112(3):814

Davies FE, Rollinson SJ, Rawstron AC, Roman E, Richards S, Drayson M, Child JA, Morgan GJ (2000) High-producer haplotypes of tumor necrosis factor alpha and lymphotoxin alpha are associated with an increased risk of myeloma and have an improved progression-free survival after treatment. J Clin Oncol Aug;18(15):2843-51. 

Haematolymphoid malignancy  

Papers - Basic research and phase 1 / 2 clinical trials

Julian C. Desmond, Joanne C. Mountford, Mark T. Drayson, Elizabeth A. Walker, Martin Hewison, Jonathan P. Ride, Quang T. Luong, Rachel E. Hayden, Elio F. Vanin, and Christopher M. Bunce (2003) The Aldo-Keto Reductase AKR1C3 Is a Novel Suppressor of Cell Differentiation That Provides a Plausible Target for the Non-Cyclooxygenase-dependent Antineoplastic Actions of Nonsteroidal Anti-Inflammatory Drugs. Cancer Research 63, 505-512

Fenton SL, Luomg QT, Sarafeim A, Mustard KJW, Pound J, Desmond JC, Gordon J, Drayson MT, Bunce CM (2003) Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt’s lymphoma cells and cell lines: potential for applying old drugs to a new disease. Leukemia 17(3):568-75

Serafeim A, Holder MJ, Grafton G, Chamba A, Drayson MT, Luong QT, Bunce CM, Gregory CD, Barnes NM, Gordon J (2003) Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells. Blood. 101(8):3212-9

Brown GB, Drayson MT, Durham J, Toellner K, Hughes PJ, Choudhry MA, Taylor DR, Bird R, Michell RH (2002) Cells halted in G1 or S phase differentiate normally. Exp Cell Res. Nov 15;281(1):28-38.

Weston VJ, Stankovic T, McMullan DJ, Drayson M, Ley BE, Lawson S, Hill FG. (2002) An unrelated cytogenetic karyotype and intra-lineage shift at relapse of an aggressive paediatric B-precursor ALL. Leukemia. Nov;16(11):2337-9

Drayson, M.T., Michell, R.H., Durham, J., Brown, G. (2001) Cell proliferation and CD11b expression are controlled independently during HL60 cell differentiation initiated by 1,25-dihydroxyvitamin D3 or all-trans-retinoic acid. Experimental Cell Research 266(1):126-34

Hughes PJ, Twist LE, Durham J, Choudhry MA, Drayson M, Chandraratna R, Michell RH, Kirk CJ and Brown G (2001) Upregulation of steroid sulphatase activity in HL60 promyelocytic cells by retinoids and 1alpha,25-dihydroxyvitamin D3. Biochemical Journal 15;355(Pt2):361-71

Brown G, Choudhry MA, Durham J, Drayson MT, Michell RH. (1999) Monocytically differentiating HL60 cells proliferate rapidly before they mature. Exp Cell Res. Dec 15;253(2):511-8.

Campbell MJ, Drayson MT, Durham J, Wallington L, Siu-Caldera ML, Reddy GS, Brown G. (1999) Metabolism of 1alpha,25(OH)2D3 and its 20-epi analog integrates clonal expansion, maturation and apoptosis during HL-60 cell differentiation. Mol Cell Endocrinol. Mar 25;149(1-2):169-83.

Fenton SL, Drayson MT, Hewison M, Vickers E, Brown G, Bunce CM. (1999) Clofibric acid: a potential therapeutic agent in AML and MDS. Br J Haematol. 1999 May;105(2):448-51.

Mountford JC, Bunce CM, Hughes SV, Drayson MT, Webb D, Brown G, Hewison M.(1999) Estrone potentiates myeloid cell differentiation: a role for 17 beta-hydroxysteroid dehydrogenase in modulating hemopoiesis. Exp Hematol. Mar;27(3):451-60.

Collaboration with Medicine (Mainly liver and renal units) and Obstetrics

Papers

Lancaster GI, Khan Q, Drysdale PT, Wallace F, Jeukendrup AE, Drayson MT, Gleeson M. (2004) Effect of prolonged exercise and carbohydrate ingestion on type 1 and type 2 T lymphocyte distribution and intracellular cytokine production in humans.
J Appl Physiol. Aug 20

Somerset DA, Zheng Y, Kilby MD, Sansom DM, Drayson MT. (2004) Normal human pregnancy is associated with an elevation in the immune suppressive CD25 CD4 regulatory T-cell subset. Immunology. May;112(1):38-43.

Clayton AR, Prue RL, Harper L, Drayson MT, Savage CO. (2003) Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses: relevance to systemic vasculitis. Arthritis Rheum. 2003 Aug;48(8):2362-74.

Harper L, Radford D, Plant T, Drayson M, Adu D, Savage CO (2001) IgG from myeloperoxidase-antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytoplasmic antibody-positive patients. Arthritis Rheum 44(4):921-30

Collaboration with Sports and Exercise Sciences

Prof D Carroll and Prof M Gleeson

Veldhuijzen Van Zanten JJ, Ring C, Burns VE, Edwards KM, Drayson M, Carroll D. (2004) Mental stress-induced hemoconcentration: Sex differences and mechanisms.
Psychophysiology. Jul;41(4):541-51.

Burns VE, Ring C, Harrison LK, Carroll D, Drayson M. (2004) Reductions in secretory immunoglobulin A to cold pressor stress are not influenced by timing of saliva sampling.
Biol Psychol. Mar;66(1):91-8.

Burns VE, Carroll D, Drayson M, Whitham M, Ring C. (2003) Life events, perceived stress and antibody response to influenza vaccination in young, healthy adults.
J Psychosom Res. Dec;55(6):569-72.

Burns VE, Carroll D, Ring C, Drayson M (2003) Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms. Vaccine 2;21:2523-34

Burns VE, Drayson M, Ring C, Carroll D. (2002) Perceived stress and psychological well-being are associated with antibody status after meningitis C conjugate vaccination. Psychosom Med. 2002 Nov-Dec;64(6):963-70.

Willemsen G, Carroll D, Ring C, Drayson M. (2002) Cellular and mucosal immune reactions to mental and cold stress: associations with gender and cardiovascular reactivity. Psychophysiology. Mar;39(2):222-8.

Burns VE, Ring C, Drayson M, Carroll D. (2002) Cortisol and cardiovascular reactions to mental stress and antibody status following hepatitis B vaccination: a preliminary study. Psychophysiology. May;39(3):361-8.

Burns VE, Carroll D, Ring C, Harrison LK, Drayson M (2002) Stress, coping, and hepatitis B antibody status. Psychosom Med. 64(2):287-93

Ring C, Drayson M, Walkey DG, Dale S, Carroll D (2002) Secretory immunoglobulin A reactions to prolonged mental arithmetic stress: inter-session and intar-session reliability. Biol Psychol 59(1):1-13

Burns VE, Drayson M, Ring C, Carroll D. (2002) Perceived stress and psychological well-being are associated with antibody status after meningitis C conjugate vaccination. Psychosom Med. 2002 Nov-Dec;64(6):963-70.

Willemsen G, Carroll D, Ring C, Drayson M. 92002) Cellular and mucosal immune reactions to mental and cold stress: associations with gender and cardiovascular reactivity. Psychophysiology. Mar;39(2):222-8.

Ring C, Harrison LK, Winzer A, Carroll D, Drayson M, Kendall M.(2000) Secretory immunoglobulin A and cardiovascular reactions to mental arithmetic, cold pressor, and exercise: effects of alpha-adrenergic blockade Psychophysiology. Sep;37(5):634-43.

Harrison LK, Carroll D, Burns VE, Corkill AR, Harrison CM, Ring C, Drayson M. (2000) Cardiovascular and secretory immunoglobulin A reactions to humorous, exciting, and didactic film presentations. Biol Psychol. 52(2):113-26.

Ring C, Carroll D, Willemsen G, Cooke J, Ferraro A, Drayson M. (1999) Secretory immunoglobulin A and cardiovascular activity during mental arithmetic and paced breathing. Psychophysiology. Sep;36(5):602-9.

Winzer A, Ring C, Carroll D, Willemsen G, Drayson M, Kendall M. (1999) Secretory immunoglobulin A and cardiovascular reactions to mental arithmetic, cold pressor, and exercise: effects of beta-adrenergic blockade. Psychophysiology. Sep;36(5):591-601.