Research activity

Current research activity falls into the following areas:

Renal

  • Angioplasty and Stent for Renal Artery Lesions.
  • DNA Repository for Glomerulonephritis.
  • Assessment of arterial stiffness in patients with chronic kidney disease.
  • Heterogeneity of injury in vasculitis.
  • B cell therapy in the treatment of ANCA associated vasculities.
  • A Phase I Study in Patients with Treatment Resistant Idiopathic Focal Segmental Glomerulosclerosis (FSGS).
  • A randomised clinical trial in remission induction in ANCA associated vasculitis.
  • Inhibitor Minimisation in Renal Transplant Recipients with Stable Allograft Function.
  • Disease assessment in systemic vasculitis.

Endocrinology

  • Polycystic Ovarian Syndrome (PCOS).
  • Progesterone metabolism and 11B-hydroxysteroid dehydrogenase activity.
  • Glucose Metabolism and Cardiovascular risk.
  • Growth hormone replacement therapy cardiovascular risk.
  • Obesity and Steroid Metabolism.
  • 11β-hydroxysteroid dehydrogenase type 1 and Hexose 6 Phosphate Dehydrogenase in the Metabolic Syndrome.
  • Intramuscular triglyceride colocalisation with mitochondria.
  • The role of local glucocorticoid generation in idiopathic osteoporosis.
  • Cortisol metabolism and impaired glucose tolerance.

SLE

  • SLE disease activity, its complications and therapy.
  • SLICC registry for atherosclerosis and malignancy in SLE.
  • Assessment of Disease Activity in Systemic Lupus Erythematosus.
  • Genetic susceptibility in systemic lupus erythematosus.
  • Long-Term Outcome of Children born to SLE patients.

Hypertension

  • Mineralocorticoid hypertension.
  • Management of patients with white coat, borderline, and confirmed hypertension.
  • The Impact of Weight Loss on Idiopathic Intracranial Hypertension.
  • Cognitive funtion in Hypertension.
  • Using control charts to monitor blood pressure.
  • A twelve week, randomized, multicentre study in patients with essential hypertension and metabolic syndrome.

Oncology

  • Prostate Cancer and Treatment.
  • Randomised controlled trial in patients with advanced renal cell carcinoma.
  • Gene and Immunotherapy for the treatment of malignant disease.
  • Androgen suppression for patients with prostate-specific-antigen progression.
  • Radiotherapy with and without synchronous chemotherapy in muscle invasive bladder cancer research.
  • Markers in patients with muscle invasive transitional cell carcinoma of the bladder.
  • A randomised Phase II trial in Hormone Refractory Prostate Cancer metastatic to  bone.
  • Chemoembolisation Techniques for Hepatocellular Carcinoma.
  • A randomised Phase III study in Metastatic Melanoma.
  • Pituitary radiotherapy.
  • A three-arm randomised controlled trial in metastatic colorectal cancer.
  • A Phase I, dose escalation trial of Recombinant Modified vaccine encoding Epstein-Barr target antigens.
  • Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy.
  • Why do some cancer patients refuse to participate in clinical trials?
  • Vaccine optimisation and assay development in a clinical trial of a vaccine for metastatic melanoma.
  • A randomised efficacy trial of herpes simplex virus HSV1716 in Recurrent Glioblastoma Multiforme.
  • Bladder Cancer Prognosis Programme.
  • British Thoracic Oncology Group Phase III trial in stage IIIB/IV non-small cell lung cancer.
  • A placebo controlled, flexible dose, randomised controlled trial in men with erectile dysfunction after pelvic surgery for rectal carcinoma.
  • A study of patients with advanced malignancies refractory to conventional anti-cancer treatments.

Other

  • Aponoeic threshold in normal healthy volunteers.
  • Supplementation as treatment for the Irritable Bowel Syndrome.
  • A study of Pulmonary Involvement in small vessel Vasculitides.
  • Nutritional assessment post liver transplant and correlation with quality of life.
  • Lipodystrophy and lipoprotein kinetics in HIV patients.
  • Optimisation of asthma therapy in adult and adolescent patients with severe persistent allergic asthma, who remain inadequately controlled.
  • Cross sectional multi-centre study of UK adults with Congenital Adrenal Hyperplasia.
  • Remission Induction in very early rheumatoid arthritis.
  • Differentiating the Mechanism of Action of Anti-TNFalpha Agents in rheumatoid arthritis, psoriatic arthritis and inflammatory bowel disease.
  • External focus feedback for motor skill acquisition after stroke
  • Energetic Abnormalities in Heart Failure with Preserved Ejection Fraction.
  • Hypocapnia and the diagnosis of early coronary artery disease.
  • The effects of obesity on venous impedance and outflow.
  • Metabolic manipulation in chronic heart failure.
  • Neuropsychological Profile of People with Craniopharyngioma.
  • A clinical pharmacology study in otherwise healthy male Hepatitis C carriers with compensated liver disease.
  • Cardiac function in patients receiving therapy for a prolactinoma.
  • Ultrasound for venous leg ulcers.

Clinics

  • Urology-Oncology Research Clinic.
  • Vasculitis Research Clinics.
  • Hypertension Research Clinics.
  • Endocrinology.