The 2013 International A-T Workshops will bring together a broad spectrum of scientists and clinicians working on various aspects of the clinical and cellular phenotypes of Ataxia Telangiectasia, ATM null deficient models and the role of ATM and ATM related pathways in neural differentiation, development, tumourigenesis and the DNA damage response.
The aims of the workshop are to:
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Share and communicate experience and expertise in understanding the rare disorder, A-T
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Provide an interdisciplinary forum to consider the multifaceted A-T disorder and ATM function
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Understand how ATM functions as a tumour suppressor
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Promote interaction between clinicians, basic and translational scientists to treat A-T and cancer
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Allow junior scientists/clinicians to meet with and learn from international experts
We have assembled a programme interfacing clinical, basic and translational scientists covering the range of disciplines relevant to A-T, of which cancer predisposition and treatment is central.
Sunday 28th July
Sunday
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18.30
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Welcome Dinner
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20.00
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Keynote Speakers
Steve Jackson
The cellular response to DNA damage - potential for therapy
EACR Sponsored Speaker
Malcolm Taylor
Ataxia telangiectasia in the British Isles
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21.30
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Close
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Monday 29th July
day 2
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08.30
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Session 1: Neurodegeneration in A-T
Chair: Peter McKinnon
Current understanding of cerebellar and non cerebellar defects in A-T Clinical assessment of the spectrum of neurological deficiency
Neuropathology of A-T
Animal models of A-T
Approaches to therapy of the neurological defect in A-T
Tom Crawford, Clinical assessment- potential for therapeutic indices
Ari Barzilai, The role of malfunctioning DDR in impaired functionality of neuro-glio-vascular unit
Rick Livesey, Neuronal stem cell development
Peter McKinnon
Gerald Shadel - Mitochondrial stress in aging and A-T: lessons from model systems
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10.30
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Refreshment Break
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11.00
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Session 2: Cancer In ataxia telangiectasia and role of ATM loss in sporadic tumours
Chair: Dominique Stoppa Lyonnet and Malcolm Taylor
Current understanding of cancer risks in both children and adults with A-T
Role of ATM in both lymphoid tumour and breast cancer development
Targeting the ATM null cellular phenotype in tumours
Malcolm Taylor, Understanding of cancer risks in children and adults with A-T
Louise Izatt, Surveillance for breast cancer in A-T families
Deborah Thompson, Epidemiology of genetic predisposition to breast cancer
Pat Concannon, Genetics of second primary breast cancer following radiotherapy
Tanja Stankovic, Targeting the ATM null phenotype
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13.00
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Lunch and Poster Session 1
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15.00
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Visit to Stratford upon Avon
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18.00
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Close
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Tuesday 30th July
day 3
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08.30
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Session 3: Immunodeficiency in A-T
Chair: Corry Weemaes
Current view of the clinical immunological deficiency in ataxia telangiectasia and ATM dependent defect in VDJ recombination/class switching
Clinical assessment of immunological defect
A-T and an aged immune system
Therapies for A-T immunodeficiency
Stefan Zielen, Frankfurt Clinical immunology of A-T/therapy of A-T
Howard Lederman, Inflammation and AT
Andrew Exley, Aging immune system and A-T
Mirjam van der Burg, Hypogammaglobulinaemia in A-T
Barry Sleckman, ATM dependent defects in VDJ recombination
Shan Zha, DNA damage response and immunodeficiency
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10.30
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Refreshments
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11.30
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Session 4: DNA damage signalling and cancer
Chair: Penny Jeggo
Susan Lees Miller
Andre Nussenzweig
Tej Pandita
Markus Lobrich- Pathways of double-strand break repair during the mammalian cell cycle
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13.00
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Lunch
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14.00
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Session 5: Treatment (therapy and stem cells)
Chair: Yossi Shiloh
Guest Speaker
Richard Gatti
Ataxia telangiectasia- the potential for therapy
Martin Lavin - Use of stem cell models to investigate the neurodegenerative phenotype in A-T
Domenica Delia - Functionality of neurons generated from A-T and NBS-derived iPS cells –title later
Luciana Chessa – Steroids in Ataxia Telangiectasia: molecular mechanisms and clinical outcomes
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17.00
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Session 7: Late breaking session
Contributed talks
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18.00
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Poster Session 2
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20.00
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Conference Dinner
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Wednesday 31st July
day 4
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08.30
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Session 8: Lessons to be learned from related diseases/genes
Guest Speaker
Oscar Fernandez Capetillo
Manuel Stucki - NBS1 and the nucleolar response to DNA double-strand breaks
Vincenzo Costanzo (accepted, no title)
Sherif El-Khamisy (Protein-linked Chromosomal Break Repair and Neurodegeration)
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10.30
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Refreshments
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11.00
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Session 10: Non-nuclear functions of ATM
Chaired by Dick Gatti
Guest Speaker
Mike Kastan
Non-nuclear functions of ATM
Ester Hammond Hypoxia-induced activation of ATM in the absence of DNA damage
Cheryl Walker
Contributed talks
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13.00
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Lunch
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14.00
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Session 6: New and breaking aspects
Guest Speaker
Yossi Shiloh
From bedside to bench and back again
EACR Sponsored Speaker
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16.00
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Refreshments
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16.30
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Close
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Programme subject to change
Many thanks to our generous sponsors