Welcome to ModNanoTox

ModNanoTox is a FP7 funded project, which started in November 2011. The project aims to develop a number of well-documented and technically advanced models describing the behaviour of engineered nanoparticles in an environmental or biological context to comprehensively address the following key hypotheses: 

  • Toxicity of nanoparticles is the result of physicochemical properties and this has been documented reliably in completed/ongoing datasets. Properties found to be relevant include size, surface area, structure and composition
  • Nanoparticle reactivity can be modelled computationally and can be linked to toxicity
  • Toxic responses from cell culture studies and whole organisms can be correlated and rationalised and can be translated into tools useful for model development
  • Bioaccumulation into cells or whole organisms can be characterized and modelled using biodynamic principles (i.e. by characterizing uptake rate constants from food and water as well as loss rate constants)
  • Toxic responses from cell culture studies and whole organisms can be modelled reliably by QSAR type approaches
  • Exposure concentrations can be assessed reliably and incorporated in appropriate models
  • Ecological effect models can be developed by extrapolation from (eco)toxicological observations and can be built into risk assessment models