Preserving musculoskeletal mass and function with age is important to strength, power and endurance, as well as metabolic health. Physical activity decreases with age, contributing significantly to loss of musculoskeletal mass and function which limit activities of daily living.
Switching to a more physically active lifestyle in older individuals could ameliorate this deterioration, but adoption of such changes is notoriously difficult to achieve.
In addition, large individual differences in the rate of musculoskeletal ageing suggest that endogenous factors have a significant impact and the Centre will focus on the role of the age-related increase in inflammatory status.
The Centre is delivering five complementary programmes of research, each led by members of our Management Board, to develop a comprehensive understanding of age-related musculoskeletal deterioration in humans, using integrative physiology, molecular biology and systems biology approaches to identify primary drivers of decline.
Novel interventions, both lifestyle (diet and exercise) and pharmacological will be evaluated and for lifestyle interventions significant effort will be placed upon developing protocols which achieve good uptake and adherence by older adults.
We are working towards these aims with the help of various colleagues and Centre funded PhD students across the Universities of Birmingham and Nottingham and the NHS.
Centre research themes: