Endocrinology, Diabetes and Metabolism
Hormones and Genes research (Endocrinology, Diabetes and Metabolism and Genetics) represents a significant research strength within the College of Medical and Dental Sciences. Current research covers a wide portfolio of basic, translational and clinical research focusing on adrenal and gonadal steroids, thyroid cancer, hyroid dsyfunction, fetal and reproductive endocrinology, pituitary disease, and auto-immunity. Ongoing studies employ a broad range of in vitro and in vivo approaches including mouse transgenic and knockout models, as well as clinical translational and interventional studies carried out in the Wellcome Trust Clinical Research Facility immediately adjacent to the Institute of Biomedical Research, the lab base for most of the Endocrine and Diabetes Groups, Clinical research is also enhanced by close interaction with the University Hospital Birmingham and cohort and database studies (thyroid disease, pituitary disease, and adrenal disease).
Research focuses on investigating the factors governing neutrophil differentiation, activation and recruitment as processes that determine the degree of tissue damage resulting in the establishment and progression of chronic lung disease. Major interests include chronic chest infections and the role of proteinases and proteinase inhibitors in this process.