May et al
Scedosporiosis is a trauma-associated fungal infection with 70% mortality and no effective treatment. It disproportionately affects individuals in resource-poor countries, following deep tissue injuries sustained during agricultural injuries or military conflict. This project aims to develop low-cost, easily administered antifungals that could be used to treat these infections. To do so, we will a) develop powerful transgenic tools in Scedosporium species, b) explore the innate immune response to these infections and c) use this information to conduct a high-throughput drug redeployment screen for novel, off-patent antifungals.
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