Selected research publications

Shown here are some of the recent outstanding publications which highlight significant advances made by researchers in our institute.

Molecular Cell (in press) Clarke TL et al.PRMT5-dependent methylation of the TIP60 coactivator RUVBL1 is a key regulator of homologous recombination.

Nat Genet (in press) Reynolds JJ et al. DONSON encodes a novel replication fork protection factor mutated in microcephalic dwarfism.

Nature Commununications 7:13087 (2016). Kotsantis P, et al. Increased global transcription activity as a mechanism of replication stress in cancer.

Nature Structural and Molecular Biology 23:647-655 (2016) Densham R, et al.  The BRCA1:BARD1 Ubiquitin ligase activity counters chromatin barriers to DNA resection.

N Engl J Med 374:1444-1454 (2016). Mehanna H, et al. PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer.

Nature Genetics 48:36-43 (2016). Harley ME, et al. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.

EMBO J  DOI 10.15252/embj.201592534 (2016). Bevington SL, et al. Inducible chromatin priming is associated with the establishment of immunological memory in T cells.

Developmental Cell. DOI: (2016). Goode et al. Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.

Molecular Cell 59:462-477 (2015). Higgs MR, et al. BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

Nature Communications 6:7203 (2015). Regha K, et al. Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.

Cell Reports 12:821-836 (2015). Cauchy P, et al. Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature.

Science 346:477-481 (2014). Moreno SP, et al. Polyubiquitylation drives replisome disassembly at the termination of DNA replication.

Nature Communications 5:3756 (2014). Cazier JB, et al. Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden.

Cell Reports 8:1974-1988 (2014). Ptasinska A, et al. Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal.

Molecular Cell 53:645-654 (2014). Feng T, et al. Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

Nature 507:381-385 (2014). Haberle V, et al. Two independent transcription initiation codes overlap on vertebrate core promoters.

Cell Reports 5:1302-1315 (2013). Sarkar S, et al. Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease.

Genome Research 23:1938-1950 (2013). Nepal C, et al. Dynamic regulation of the transcription initiation landscape at single nucleotide resolution during vertebrate embryogenesis.

EMBO Reports 14:975-983 (2013). Garvin AJ, et al. The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair.

Lancet Oncology 13:1152-1160 (2012). Foxtrot Collaborative Group/Morton D. Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: the pilot phase of a randomised controlled trial.

Molecular Cell 45:505-516 (2012). Polo SE, et al. Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.

Cell Reports 2:270-282 (2012). Radulescu S, et al. Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo.

EMBO J 31:3918-3934 (2012). Butler LR, et al. The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response.

EMBO J 31:4318-4333 (2012). Lichtinger M, et al. RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.

Nature Chemical Biology 8:960-962 (2012). Ge W, et al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.

Lancet 377:321-331 (2011). van de Velde CJ, et al. Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial.

Cancer Cell 20:797-809 (2011). Drost R, et al. BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

Molecular Cell 43:19-32 (2011). Sarkar S, et al. Complex inhibitory effects of nitric oxide on autophagy.

Nature Genetics 43:1169-1170 (2011). Lin H, et al. Relative overexpression of X-linked genes in mouse embryonic stem cells is consistent with Ohno's hypothesis.

PNAS 107:10799-10803 (2010). Ludwig C, et al. Quantum rotor induced hyperpolarization.

Nature Cell Biology 12:963-972 (2010). Davies CC, et al. Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.

Molecular Cell 37:492-502 (2010). Petermann E, et al. Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

Proc Natl Acad Sci U S A 107:16090-16095 (2010). Petermann E, et al. Chk1 promotes replication fork progression by controlling replication initiation.

Lancet Neurology 9:581-591 (2010). Williams A, et al. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial.

PNAS 107:12251-12256 (2010). Blackford AN, et al. Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.