Our group is interested in the role Epstein-Barr virus (EBV) plays in the pathogenesis of nasopharyngeal carcinoma (NPC) and a subset of gastric carcinomas. This work has ranged from the examination of EBV gene expression in these tumours to functional analysis of individual EBV latent genes in epithelial cells.
The role of epithelial cell infection in EBV persistence and replication has also been examined with particular emphasis on viral modulation of cellular signalling pathways that impact on these processes. The contribution of EBV strain variation to tumour development has also been studied.
(ii) the first demonstration of the pattern of EBV gene expression in nasopharyngeal carcinoma;
(iii) the signalling function of EBV-encoded latent proteins.
John R. Arrand (group lead)
Dr Christopher Dawson (group lead)
Rebecca J. Port