Selected recent publications

Here is a selection of our recent high impact publications. To view the full range from our expert scientists on staff profiles visit the Our Staff page. 

 
Author(s) Title Journal and date
Fletcher SJ, Johnson B, Lowe GC, Bem D, Drake S, Lordkipanidzé M, Guiú IS, Dawood B, Rivera J, Simpson MA, Daly ME, Motwani J, Collins PW, Watson SP, Morgan NV.

SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects.



J Clin Invest. 2015 Sep 1;125(9):3600-5. doi: 10.1172/JCI80347. Epub 2015 Aug 17.
Chimen M, McGettrick HM, Apta B, Kuravi SJ, Yates CM, Kennedy A, Odedra A, Alassiri M, Harrison M, Martin A, Barone F, Nayar S, Hitchcock JR, Cunningham AF, Raza K, Filer A, Copland DA, Dick AD, Robinson J, Kalia N, Walker LS, Buckley CD, Nash GB, Narendran P, Rainger GE 

Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. 

 

Nat Med. 2015 May;21(5):467-75. doi: 10.1038/nm.3842. Epub 2015 Apr 20.
Alshehri OM, Hughes CE, Montague S, Watson SK, Frampton J, Bender M, Watson SP. Fibrin activates GPVI in human and mouse platelets.

 

Blood. 2015 Sep 24;126(13):1601-8. doi: 10.1182/blood-2015-04-641654. Epub 2015 Aug 17.
Mazharian A, Wang YJ, Mori J, Bem D, Finney B, Heising S, Gissen P, White JG, Berndt MC, Gardiner EE, Nieswandt B, Douglas MR, Campbell RD, Watson SP, Senis YA.

Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function. 

Sci Signal. 2012 Oct 30;5(248):ra78. doi: 10.1126/scisignal.2002936.
Kotecha D, Holmes J, Krum H, Altman DG, Manzano L, Cleland JG, Lip GY, Coats AJ, Andersson B, Kirchhof P, von Lueder TG, Wedel H, Rosano G, Shibata MC, Rigby A, Flather MD; Beta-Blockers in Heart Failure Collaborative Group.

Efficacy of β blockers in patients with heart failure plus atrial fibrillation: an individual-patient data meta-analysis. 

Lancet. 2014 Dec 20;384(9961):2235-43. doi: 10.1016/S0140-6736(14)61373-8. Epub 2014 Sep 2.
Kirchhof P, Kahr PC, Kaese S, Piccini I, Vokshi I, Scheld HH, Rotering H, Fortmueller L, Laakmann S, Verheule S, Schotten U, Fabritz L, Brown NA.

PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.

Circ Cardiovasc Genet. 2011 Apr;4(2):123-33. doi: 10.1161/CIRCGENETICS.110.958058. Epub 2011 Jan 31.
Noy PJ, Lodhia P, Khan K, Zhuang X, Ward DG, Verissimo AR, Bacon A, Bicknell R.

Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth.

Oncogene. 2015 Mar 9. doi: 10.1038/onc.2015.34. [Epub ahead of print]
Moody WE, Edwards NC, Madhani M, Chue CD, Steeds RP, Ferro CJ, Townend JN. Endothelial dysfunction and cardiovascular disease in early-stage chronic kidney disease: cause or association? Atherosclerosis. 2012 Jul;223(1):86-94. doi: 10.1016/j.atherosclerosis.2012.01.043. Epub 2012 Feb 2.
 Lip GY, Lane DA. Stroke prevention in atrial fibrillation: a systematic review. JAMA. 2015 May 19;313(19):1950-62. doi: 10.1001/jama.2015.4369.
Poulter NS, Pollitt AY, Davies A, Malinova D, Nash GB, Hannon MJ, Pikramenou Z, Rappoport JZ, Hartwig JH, Owen DM, Thrasher AJ, Watson SP, Thomas SG
Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex. Nat Commun. 2015 Jun 1;6:7254. doi: 10.1038/ncomms8254.