Birmingham Platelet Group

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Overview 

The Birmingham Platelet Group adopts a multidisciplinary approach in the investigation of platelet and megakaryocyte biology, which ranges from cell biology, signal transduction and functional studies through to the use of mouse models and studies on patients.

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Current Projects

  • Cell surface receptors and their signalling pathways, including ITAM and ITIM receptors, Src and Syk tyrosine kinases, and protein-tyrosine phosphatases
  • The genetics of platelet bleeding disorders
  • Megakaryocytopoiesis and platelet formation
  • Models of venous and arterial thrombosis
  • Animal models of cardiovascular diseases
  • Actin polymerisation and advanced microscopy
  • Platelet function testing
  • Granule biogenesis and secretion
  • Role of platelets in development and inflammatory processes
  • Extracellular vesicles
  • Platelet procoagulant activity

Selected Publications

For full publications lists see:

Staff

Principal Investigators
Alexander Brill
Paul Harrison
Alexandra Mazharian
Neil Morgan
Jun Mori
Natalie Poulter
Yotis Senis
Steve Thomas
Steve Watson

Postdoctoral researchers
Sarah Jane Fletcher
Elisabeth Haining
Sian Lax
Zoltan Nagy
Marie-Blanche Onselaer
Tatyana Ponomaryov
Zaher Raslan
Julie Rayes
Timo Voegtle
Malou Zuidscherwoude

 PhD/MD Students
Miss Chiara Pallini
Mr Mitchell Geer
Mr Christopher Smith
Miss Stephanie Lombard
Mr Alexander Hardy
Miss Annabel Maclachlan
Dr Pip Nicolson
Miss Holly Payne
Mr Abhi Chauhan
Mr Rashid Al Ghaithi
Mr Robert Dinsdale
Dr Dannie Seddon
Mr Abdullah Khan
Mr Surasak Wichaiyo

Research Technicians
Dr Silke Heising
Miss Stephanie Watson
Miss Beata Grygielska
Miss Giada Di Nunzio
Miss Ying Di
Miss Pushpa Patel

Research Co-Ordinator
Mrs Gayle Halford

Close ties with other Principal Investigators on platelet related projects
Professor Roy Bicknell - Professor of Functional Genomics
Dr Andrew Blann - Non-clinical Senior Lecturer
Dr Neena Kalia - Senior Lecturer in Cardiovascular Sciences
Professor Gregory Y H Lip - Consultant Cardiologist & Prof of Cardiovascular Medicine
Dr Melanie Madhani - Senior Lecturer in Cardiovascular Medicine
Professor Gerard Nash - Professor of Cardiovascular Rheology
Professor Ed Rainger - Professor of Chronic Inflammation
Dr Michael Tomlinson - Senior Lecturer in the School of Biosciences
Dr Gillian Lowe - Consultant in Haemostasis and Thrombosis / Hon Senior Lecturer
Dr Mike Williams - Consultant Paediatric Haematologist/Honorary Lecturer