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Biology is currently going through profound changes: The development of whole-genome sequencing and functional genomics has allowed characterizing cells and organisms at an unprecedented level of detail.
The information now available represents every level of biological organization and includes quantitative measurements of genes and protein expression and metabolite concentrations, protein-protein interactions and their structures. The need to organize and mine these datasets has stimulated the development of computational methods to reduce this information into systems-level models of biological processes and whole organisms. Regardless of the field of application, mathematical modeling is rapidly becoming an integral part of a modern biology laboratory.
From a methodological perspective we are developing and applying computational methods to reconstruct and analyze the underlying structure of biological networks, to model the interactions between proteins and to model whole organisms. We work on many relevant biological systems including Bacteria, Yeast, and higher vertebrates.