Deryn is interested in contemporary biblical hermeneutics, specifically in the ways gender theory and queer theory is utilized in the interpretation of scriptural texts. Her work currently engages with the disciplinary boundaries of feminist biblical scholarship, problematising its agenda, methodologies and politics by pioneering a lesbian-identified hermeneutic. Her interest in theories of gender, sexuality, and race inform work on lesbian, gay, bisexual and transgender interpretations of scripture in a range of contemporary global contexts and the role of the Bible in contemporary political debate relating to lesbian, gay and transgender human rights. Applications of this include the imaging of masculinity and femininity in the Hebrew and Christian scriptures, the role of women within Ancient Israelite society, and the interpretation of texts in the light of contemporary hermeneutical theory.