Here is a list of all the research activity pages:
- Research involves a series of internationally recognised research groups investigating different aspects of immune system control. These groups study basic mechanisms and apply this knowledge to selected diseases with the aim of identifying improved methods of treatment. Strengths in these areas are recognised through the establishment by the Medical Research Council of the Birmingham Centre for Immune Regulation. The Centre was established in 1999 to provide a focus for existing immunology programmes in Birmingham and to add value by promotion collaboration and providing key technologies fundamental to state of the art immunological research. By gaining insights into the microenvironmental control of immune responses, the global aim of our research is to gain a better understanding of the cellular and molecular mechanisms controlling autoimmunity, immune-mediated inflammatory disease and infectious disease. Efforts are focussed on common diseases involving autoimmune or dysregulated responses which are associated with a major health burden and socio-economic impact. These include responses to chronic viral infection, selected bacterial infections, inflammatory disease in joints, kidney and liver, autoimmune systemic vasculitis and autoimmune islet destruction in diabetes. Defining the molecular basis of chronic inflammation is a major focus of research that is already identifying convergent pathways and providing novel therapeutic targets. Birmingham has been at the forefront of research into chronic inflammation for more than 10 years and we are exploiting this strong base in biomedical research to develop translational studies in patients and implement new therapies for chronic inflammatory disease.
- Immunity and infection research at University of Birmingham is investigating immune regulation in health and disease together with mechanisms of infection and antibiotic resistance to help design better therapies for the future. We employ a large and successful cohort of internationally recognised scientists looking at fundamental mechanisms involved in immune regulation, infection and immune mediated inflammation. Key research areas are Rheumatoid Arthritis, inflammatory liver and kidney disease, lupus, ocular inflammation, type 1 diabetes, hepatitis C, bacterial pathogenesis and antibiotic resistance.
- INFLAME consortium only webpages.
- Chronic inflammation drives diseases from rheumatoid arthritis, atherosclerosis and obesity to immune mediated tissue destruction and scarring of the liver and kidney. It is thus a major cause of chronic disease, morbidity and mortality in the UK. In Birmingham we are elucidating the pathophysiological mechanisms through multidisciplinary translational research. Our internationally recognised research in immune regulation, including cross-cutting expertise in cell trafficking and cellular interactions within tissue microenvironments, underpins a process driven analysis of human disease pathogenesis. The work is integrated with and supported by clinical studies of well-characterised patient cohorts. Knowledge gained from our research is being used to improve the delivery of treatment through the application of biomarkers to characterise, monitor and treat disease and the identification of new therapeutic targets. Our focus is on inflammatory diseases of the joint, eye, liver and kidney.