Dementia is a progressive loss of memory, intellect and personality that affects almost 1 million people in the UK. The most prevalent form of Dementia is Alzheimer’s disease. As there are no early diagnostic methods and no disease modifying therapy the personal, social and economic burden of dementia is set to increase rapidly in the ageing population.
The main aim of this group is to decipher the cellular and molecular mechanisms in the brain that lead to the development of Alzheimer’s disease. Our working hypothesis, the cell cycle theory of Alzheimer’s disease, allowed us to develop novel biomarkers for the disease and screen for novel disease modifying drugs.
In collaboration with Professor Carl Clarke, Professor Karen Morrison, Dr Peter Bentham and the University of Oxford based Thomas Willis Brain Bank we are also working towards the discovery of novel genetic variants that could increase the risk of Alzheimer’s disease.
Professor Carl Clarke
Professor Karen Morrison
Dr Zsuzsanna Nagy
Professor Timothy Barrett - School of Clinical and Experimental Medicine, College of Medical and Dental Sciences
Dr Sarah Aldred - School of Sports and Exercise Science, College of Life and Environmental Sciences
Dr Peter Bentham - Consultant Psychiatrist for the Birmingham Working Age Dementia Service and Honorary Senior Clinical Lecturer at the University of Birmingham, UK
Professor MM Esiri - University of Oxford, UK
Professor AD Smith - University of Oxford, UK
Professor G Wilcock - University of Oxford, UK