Major strategic goals in the development of the Centre include the Centre for Obesity Research, which was pump-primed through alumni activity, and represents a collaborative inter-disciplinary cross-College ventures with a clear NHS interface.
CEDAM research is committed to a bench-to-bedside approach, taking research through from basic science discovery to clinical application. This is facilitated by current MRC Experimental Medicine and Biomarker Grants and enhanced by the close proximity of lab facilities, Wellcome Trust Clinical Research Facility and the Queen Elizabeth Hospital (University Hospital NHS Foundation Trust)
Some recent highlights of CEDAM research include
- elucidation of the role of cortisol metabolism in human obesity, hypertension and chronic inflammatory conditions
- the discovery of the endocrine and genetic basis of androgen excess disorders, including polycystic ovary syndrome and congenital adrenal hyperplasia
- endocrine autoimmune disease
- understanding of underlying mechanisms determining the influence of maternal endocrinology on fetal development has also been achieved
Clinical research has advanced the treatment of diabetes and its complications and the management of thyroid, adrenal, gonadal and pituitary disease.
Both basic science and translational genetic research has yielded important insights into the pathogenesis of endocrine cancers, especially thyroid cancer, as well as rare but important inherited disorders in childhood.
Lead: Wiebke Arlt