• MRC Clinician Scientist & Consultant Transplant Hepatologist (2012)
• CCST General Internal Medicine/Gastroenterology 2011
• PhD  (Regulatory T cells and Th17/Tc17 subsets) 2010
• Member of Royal College of Physicians 2001
• MBBS 1995

Ye qualify in Medicine in 1995 from Rangoon, Burma. He joined West Midlands Gastroenterology/Hepatology training programme in 2002 where received his training in Gastroenterology/ General Internal Medicine and Transplant Hepatology. He studied PhD on Hepatic Immunology particularly focusing on hepatic tolerance and human Regulatory T cells and intrahepatic lymphocyte subsets balance in liver inflammation and repair in 2006 under supervision of Prof David Adams at Liver Laboratory. Following that he invested a year isolating GMP grade regulatory T cells whilst involving in HCV therapeutic vaccination and Directly Acting Anti-viral clinical trials for HCV and VIRGIL project on Hepatitis B.

He completed his clinical training in 2011. He received a Clinician Scientist fellowship award from Medical Research Council in Jan 2012 to investigate both basic and preclinical study on Regulatory T cells homing and future translational therapy. He joined his colleagues in Liver Medicine clinical team as a Consultant Transplant Hepatologist in Jan 2012.

He currently holds Medical Research Council Intermediate Fellowship Grant and University of Birmingham Charity Grant.

Teaching Programmes

• Medical Science BMedSc 
• MRCP PACES

Ye is interested in supervising PhD on research fellows and students in the following areas:

• Basic pathogenesis of hepatic inflammation and repair in viral and autoimmune hepatitis.
• Autologous Regulatory T cell therapy to restore immune homeostasis in autoimmune hepatitis and liver transplantation.

If you are interesting in studying any of these subject areas please contact Ye on y.h.oo@bham.ac.uk or the contact details above.

RESEARCH THEMES

Regulatory T cells, Immune cell and cytokines therapy, Viral immunology, Clinical Trials

RESEARCH ACTIVITY

He leads a small research team. His laboratory research is focused on intrahepatic signals, which switch the effector and regulatory immune cells network balance in the context of liver inflammation. He mainly investigates the regulatory T cells in inflamed microenvironment. He is now trying to develop GMP grade Human Regulatory T cells for future immunotherapy for liver diseases within the NIHR BRU Centre for Liver Disease in Birmingham.

• Honorary Consultant Hepatologist
• Member British Association for Study of the Liver
• Member European Association for Study of the Liver
• Member of British Viral Hepatitis Group

Lucy J Walker, Yuhoi H Kang, Matthew O Smith, Hannah Tharmalingham, Ye Htun Oo, Thomas J Scriba, Willem A Hanekom, Georg M Lauer, David H Adams , Eleanor Barnes, Paul Klenerman. Human CD8ααT cells are a CD161++ subset with distinct functional characteristics. (Blood, 2011 Nov)

YH Oo, C Weston, P F Lalor, S Curbishley, DR Withers, GM Reynolds, S Shetty, J Harki, JC Shaw, B Eksteen, SG Hubscher, LS Walker, DH Adams Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver; ( Journal of Immunology; 2010 Mar 15;184(6):2886-98)

Billerbeck E, Kang YH, Walker L, Lockstone H, Grafmueller S, Fleming V, Flint J, Willberg CB, Bengsch B, Seigel B, Ramamurthy N, Zitzmann N, Barnes EJ, Thevanayagam J, Bhagwanani A, Leslie A, YH Oo, Kollnberger S, Bowness P, Drognitz O, Adams DH, Blum HE, Thimme R, Klenerman P. Analysis of CD161 expression on human CD8+ T cells defines a functional subset with tissue-homing properties; (Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3006-11)

WK Syn, YH Oo, Thiago A Pereira1,Gamze F Karaca1, Youngmi Jung1,Alessia Omenetti1,Rafal P Witek, Steve S Choi1,Cynthia D Guy, Caitlin M Fearing Vanessa Teaberry,Fausto E L Pereira1,David H Adams, Anna Mae Diehl Accumulation of NKT cells in progressive NASH,. (Hepatology. 2010 Jun;51(6):1998-2007)

Hennes EM, YH Oo, Schramm C, Denzer U, Buggisch P, Wiegard C, Kanzler S, Schuchmann M, Boecher W, Galle PR, Adams DH, Lohse AW. Mycophenolate mofetil as second line therapy in Autoimmune Hepatitis; Am J Gastroenterology. 2008 Dec; 103(12):3063-70.

Shishir Shetty, Christopher Weston, Ye Htun Oo, Nina Westerlund, Zania Stamataki, Janine Youster, Stefan Hubscher, Marko Salmi, Sirpa Jalkanen, Patricia Lalor, David H Adams Clever-1 mediates the transmigration of T regulatory cells across human hepatic sinusoidal endothelium. (J Immunol. 2011 Apr 1;186(7):4147-55)

YH Oo, DH Adams Autoimmune Hepatitis; New treatment paradigm; Hepatology International, 2010 May 19;4(2):475-93

YH Oo, T Dudley, P Nightingale, G Haydon, D Mutimer.Tacrolimus and Cyclosporin doses and blood levels in Hepatitis C and Alcoholic liver disease patients after liver transplantation; Liver Transplantation 2008, Jan 14(1) 81-87