Dr Patricia Lalor PhD, BSc

Senior Lecturer

School of Immunity and Infection

Contact details

Centre for Liver Research
Institute of Biomedical Research
School of Immunity and Infection
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

About

Dr Lalor is a Senior Lecturer in The Centre for Liver Research with an interest in inflammation, endothelial biology and regulation of liver metabolism.

Trish has published over 50 research papers as well as reviews and book chapters in the fields of leucocyte recruitment, endothelial biology and liver disease. Her research has been supported by research grants from The Medical Research Council, The Wellcome Trust, BBSRC, NIH and The European Union and by collaborations with industry. Trish is a STEM ambassador and has actively engaged in outreach and public engagement activities such as ‘The Big Bank 2012’, and ‘Meet the Scientists’ at Think Tank Birmingham, and visits schools to promote science education and clinical research to a wider audience.

Qualifications

  • Foundation of Learning and Teaching in Higher Education(2012)
  • PhD medicine (1998)
  • BSc Hons Applied Biology (1994)

Biography

Dr Lalors' undergraduate degree course in Biological Sciences provided the opportunity to take a year out in industry. She was fortunate to secure a placement in the laboratory of Professor Gerard Nash where she performed studies of platelet and leucocyte recruitment using his in vitro, flow based adhesion assays. On the back of this successful project Trish was offered funding to return to Professor Nash’s group to complete PhD studies investigating the role of a specific adhesion molecule, VCAM-1 in lymphocyte recruitment.

She then moved to the laboratory of Professor David Adams to establish flow-based adhesion technology for application to investigation of inflammation in the human liver. Here whilst continuing to investigate pathways of immune cell recruitment and retention in the human liver she also extended her research to specifically investigate the unique functions of hepatic sinusoidal endothelium.

Dr Lalor was appointed as a lecturer in Immunity and Infection 2007 and awarded a Senior Lectureship in 2013.

Teaching

Postgraduate supervision

Trish is a PhD supervisor for clinical fellows and basic science students, and also supervises MRes and MSc students in the school.

Trish is currently supervising doctoral research students in the areas of liver inflammation, endothelial biology and MALDI imaging of the liver.

For any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.   

Research

RESEARCH THEMES

: Inflammatory and metabolic liver disease in humans, inflammation and leucocyte recruitment, endothelial biology and liver cell biology

CURRENT RESEARCH ACTIVITY : Current research projects are focused upon understanding the molecular regulation of glucose and lipid homeostasis in human fatty liver disease. Present studies are also considering extrahepatic manifestations of fatty liver injury. Regulation of inflammation and immune or stem cell recruitment, remain key areas of interest and in particular the contribution of platelets and key adhesion receptors in the liver and bowel. Human hepatic cell biology and the unique functions of sinusoidal endothelium remain a focus of the experimental strategies used.


Other activities

  • Associate Fellow of the Higher Education Academy.
  • STEM ambassador involved in local and national outreach events
  • Currently a member of the editorial board of the ‘World Journal of Gastroenterology’ and World Journal of Hepatology and also act as a language editor for these journals.
  • Formerly served on the editorial board of the journal ‘Transplantation’.
  • Member of the school faculty for The European Association for the Study of the Liver (EASL) Basic Hepatology School, and has served as a scientific representative on the committee responsible for The British Association for the Study of the Liver (BASL).
  • Reviewer for professional journals including :  ‘PLOSone’, ‘Cell transplantation’, ‘Gut’, ‘Hepatology’, ‘Journal of Leukocyte Biology’, ‘The American Journal of Transplantation’, ‘Inflammation Research’, ‘American Journal of Pathology’ ‘American Journal of Physiology’ ‘Liver International’ and ‘Liver Transplantation’.

 

Publications

Formal Lithium Fixation Improves Direct Analysis of Lipids in Tissue by Mass Spectrometry. Griffiths RL, Sarsby J, Guggenheim EJ, Race AM, Steven RT, Fear J, Lalor PF, Bunch J. Analytical chemistry 2013 :

The regulation of T-cell recruitment to the human liver during acute liver failure. Tuncer C, Oo YH, Murphy N, Adams DH, Lalor PF. Liver international : official journal of the International Association for the Study of the Liver 2013 33:  852-63

Hyperspectral visualization of mass spectrometry imaging data. Fonville JM, Carter CL, Pizarro L, Steven RT, Palmer AD, Griffiths RL, Lalor PF, Lindon JC, Nicholson JK, Holmes E, Bunch J. Analytical chemistry 2013 85:  1415-23

An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells. Karim S, Liaskou E, Hadley S, Youster J, Faint J, Adams DH, Lalor PF. Toxicological sciences : an official journal of the Society of Toxicology 2013 132:  131-41

Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment. Lalor PF, Herbert J, Bicknell R, Adams DH. American journal of physiology. Gastrointestinal and liver physiology 2013 304:  G469-78

Hepatic expression and cellular distribution of the glucose transporter family. Karim S, Adams DH, Lalor PF. World journal of gastroenterology : WJG 2012 18:  6771-81

Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics. Liaskou E, Zimmermann HW, Li KK, Oo YH, Suresh S, Stamataki Z, Qureshi O, Lalor PF, Shaw J, Syn WK, Curbishley SM, Adams DH. Hepatology (Baltimore, Md.) 2013 57:  385-98

Recruitment mechanisms of primary and malignant B cells to the human liver. Shetty S, Bruns T, Weston CJ, Stamataki Z, Oo YH, Long HM, Reynolds GM, Pratt G, Moss P, Jalkanen S, Hubscher SG, Lalor PF, Adams DH. Hepatology (Baltimore, Md.) 2012 56:  1521-31

Human mesenchymal stem cells are recruited to injured liver in a β1-integrin and CD44 dependent manner. Aldridge V, Garg A, Davies N, Bartlett DC, Youster J, Beard H, Kavanagh DP, Kalia N, Frampton J, Lalor PF, Newsome PN. Hepatology (Baltimore, Md.) 2012 56:  1063-73

Functional consequences of human lymphocyte cryopreservation: implications for subsequent interactions of cells with endothelium. Faint JM, Tuncer C, Garg A, Adams DH, Lalor PF. Journal of immunotherapy (Hagerstown, Md. : 1997) 201134:  588-96

Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium. Shetty S, Weston CJ, Oo YH, Westerlund N, Stamataki Z, Youster J, Hubscher SG, Salmi M, Jalkanen S, Lalor PF, Adams DH. Journal of immunology (Baltimore, Md. : 1950) 2011 186:  4147-55

Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity. Liaskou E, Karikoski M, Reynolds GM, Lalor PF, Weston CJ, Pullen N, Salmi M, Jalkanen S, Adams DH. Hepatology (Baltimore, Md.) 2011 53:  661-72

Identifying homing interactions in T-cell traffic in human disease. Lalor PF, Curbishley SM, Adams DH. Methods in molecular biology (Clifton, N.J.) 2010 616:  231-52

Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH. Journal of immunology (Baltimore, Md. : 1950) 2010 184:  2886-98

Haematopoietic stem cell recruitment to injured murine liver sinusoids depends on (alpha)4(beta)1 integrin/VCAM-1 interactions. Kavanagh DP, Durant LE, Crosby HA, Lalor PF, Frampton J, Adams DH, Kalia N. Gut 2010 59:  79-87

Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver. Holt AP, Haughton EL, Lalor PF, Filer A, Buckley CD, Adams DH. Gastroenterology 2009 136:  705-14

CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow. Miles A, Liaskou E, Eksteen B, Lalor PF, Adams DH. American journal of physiology. Gastrointestinal and liver physiology 2008294:  G1257-67

Hepatitis C virus receptor expression in normal and diseased liver tissue. Reynolds GM, Harris HJ, Jennings A, Hu K, Grove J, Lalor PF, Adams DH, Balfe P, Hübscher SG, McKeating JA. Hepatology (Baltimore, Md.) 2008 47:  418-27

Vascular adhesion protein-1 as a potential therapeutic target in liver disease. Lalor PF, Tuncer C, Weston C, Martin-Santos A, Smith DJ, Adams DH. Annals of the New York Academy of Sciences 2007 1110:  485-96

The role of cytokines and chemokines in the development of steatohepatitis. Lalor PF, Faint J, Aarbodem Y, Hubscher SG, Adams DH. Seminars in liver disease 2007 27:  173-93

Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion. Lalor PF, Sun PJ, Weston CJ, Martin-Santos A, Wakelam MJ, Adams DH. Hepatology (Baltimore, Md.) 2007 45:465-74

An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG. The Journal of experimental medicine 2006 203:  2763-77

Vitronectin in human hepatic tumours contributes to the recruitment of lymphocytes in an alpha v beta3-independent manner.Edwards S, Lalor PF, Tuncer C, Adams DH. British journal of cancer 2006 95:  1545-54

Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo. Lalor PF, Lai WK, Curbishley SM, Shetty S, Adams DH. World journal of gastroenterology : WJG 2006 12:  5429-39

Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. Lai WK, Sun PJ, Zhang J, Jennings A, Lalor PF, Hubscher S, McKeating JA, Adams DH. The American journal of pathology 2006 169:  200-8

CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.Curbishley SM, Eksteen B, Gladue RP, Lalor P, Adams DH. The American journal of pathology 2005 167:  887-99

Endothelial interactions of neutrophils under flow in chronic obstructive pulmonary disease. Woolhouse IS, Bayley DL, Lalor P, Adams DH, Stockley RA. The European respiratory journal 2005 25:  612-7

Lymphocyte traffic through sinusoidal endothelial cells is regulated by hepatocytes. Edwards S, Lalor PF, Nash GB, Rainger GE, Adams DH. Hepatology (Baltimore, Md.) 2005 41:  451-9

CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangiocytes and hepatocytes within the inflamed human liver. Heydtmann M, Lalor PF, Eksteen JA, Hübscher SG, Briskin M, Adams DH. Journal of immunology (Baltimore, Md. : 1950) 2005 174:  1055-62

Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis. Eksteen B, Grant AJ, Miles A, Curbishley SM, Lalor PF, Hübscher SG, Briskin M, Salmon M, Adams DH. The Journal of experimental medicine 2004 200:  1511-7

The liver: a model of organ-specific lymphocyte recruitment. Lalor PF, Adams DH. Expert reviews in molecular medicine 2002 4:  1-16

Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells. Lalor PF, Edwards S, McNab G, Salmi M, Jalkanen S, Adams DH. Journal of immunology (Baltimore, Md. : 1950) 2002 169:  983-92

Lymphocyte recruitment to the liver in alcoholic liver disease. Haydon G, Lalor PF, Hubscher SG, Adams DH. Alcohol (Fayetteville, N.Y.) 2002 27:  29-36

Recruitment of lymphocytes to the human liver. Lalor PF, Shields P, Grant A, Adams DH. Immunology and cell biology 200280:  52-64

Heparin therapy for ulcerative colitis? Effects and mechanisms. Michell NP, Lalor P, Langman MJ. European journal of gastroenterology & hepatology 2001 13:  449-56

Lymphocyte homing to allografts. Lalor PF, Adams DH. Transplantation 2000 70:  1131-9

Adhesion of lymphocytes to hepatic endothelium. Lalor PF, Adams DH. Molecular pathology : MP 1999 52:  214-9

Association between receptor density, cellular activation, and transformation of adhesive behavior of flowing lymphocytes binding to VCAM-1. Lalor PF, Clements JM, Pigott R, Humphries MJ, Spragg JH, Nash GB. European journal of immunology 1997 27:  1422-6

Adhesion of flowing leucocytes to immobilized platelets. Lalor P, Nash GB. British journal of haematology 1995 89:  725-32

Back to top