Cellular, Immune and Gene Therapy for Cancer

 Hodgkin's lymphoma with H-RS Cells (green) and CXCR3 positive T cells (pink)

This theme involves the development and clinical trialling of novel therapies for cancer based on two principles

  • using the specificity of the cellular immune system to recognise and kill tumour cells selectively
  • using vector-mediated delivery to tumour cells of genes that sensitise the cells to chemotherapeutic pro-drugs.

For both approaches, viruses provide an important entrée. Thus virus-associated cancers are key targets of choice for the development of immune therapies, while other viruses provide the key vectors for tumour-specific gene delivery.  

This work complements and extends that described in the Viral Oncology Theme.

Immunotherapy research