Angiogenesis Group

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Group leaders: Prof Roy Bicknell and Dr Victoria Heath

Overview

The goal of our research is to better understand the process of blood vessel formation and identify new markers found on tumour vessels.  Identification of tumour vessel markers will enable the development of new anti-cancer therapies.  In addition, understanding the complex molecular events involved in vessel formation will reveal new ways to modulate this process in various pathologies.

Our research group

The research of our group is focussed on studying angiogenesis and in the discovery of novel tumour endothelial markers.  Angiogenesis plays a pivotal role in the pathogenesis of solid tumours, enabling both their growth and metastasis.  The abnormal tumour microenvironment causes tumour vessels to be phenotypically distinct from their normal counterparts.  A key aim of our group is to better characterise the transcriptome of tumour vessels in a range of human tumours, to enable the identification of novel tumour endothelial markers which could be used to develop new anti-tumour therapies.  We are also undertaking basic research to interrogate the mechanisms of angiogenesis and in particular are studying the molecular functions of Robo4, Clec14a, ECSCR and RhoJ proteins which our group have identified as having a role in endothelial motility and tube formation.  We use a wide variety of assays and techniques to investigate the functions of these and novel tumour endothelial markers.

Current Projects

  • Understanding the molecular role of ECSCR in angiogenesis
  • Characterisation of the molecular interactions of Clec14a and their role in angiogenesis
  • Identification of novel tumour endothelial markers from lung and colon cancer
  • Bioinformatic analysis of endothelial non-coding RNA
  • Characterisation of the role of RhoJ in endothelial motility and tube formation

Recent Publications

For full publication lists see:

Staff

Principal Investigators
Prof Roy Bicknell – School of Immunity and Infection
Dr Victoria Heath – School of Immunity and Infection

Postdoctoral Researchers
Dr Peter Noy – School of Immunity and Infection
Dr Samantha Tull – School of Immunity and Infection

PhD Students
Rosemary Bamford – School of Immunity and Infection
Henry Ferguson – School of Immunity and Infection
David Kershaw – School of Immunity and Infection
Kabir Khan – School of Immunity and Infection
Puja Lodhia – School of Immunity and Infection
Victoria Salisbury – School of Immunity and Infection
Klarke Sample – School of Immunity and Infection
Eleanor Wilson – School of Immunity and Infection
Joseph Wragg – School of Immunity and Infection

Other Related Staff
Paul Newby - School of Immunity and Infection

Internal Collaborators
Dr Steven Lee - School of Cancer Sciences
Dr Ashley Martin - School of Cancer Sciences
Dr Zsuzsanna Nagy - School of Clinical and Experimental Medicine
Prof Gerard Nash - School of Clinical and Experimental Medicine
Prof Ed Rainger - School of Clinical and Experimental Medicine
Dr Joshua Rappoport - School of Biosciences
Dr Kai Toellner – School of Immunity and Infection
Dr Michael Tomlinson - School of Biosciences
Prof Ben Willcox - School of Cancer Sciences

External Collaborators
Prof Stuart Egginton – University of Leeds