The 4 respiratory clinical lecturers work within three main disease areas: chronic obstructive pulmonary disease (COPD), lung cancer and acute lung injury (ALI). Within COPD there is ongoing work pertaining to the role of the neutrophil, the concept of lung aging, differences between COPD and alpha 1 antitrypsin deficiency (AATD), genetic modifiers of COPD and the role of vitamin D and its binding protein.
Research into mechanisms of COPD co-morbidity has also begun recently, and we collaborate with public health for wider epidemiological work in COPD and its co-morbidities. In lung cancer we are interested predominantly in the role of tumour associated macrophages, but have collaborations that are active in wider cancer biology. Within ALI there is parallel work examining the role of various parts of the vitamin D axis in pathogenesis, as well as aspects of macrophage biology.
Alice Wood (group lead), Clinical Lecturer
Elizabeth Sapey (group lead)
Rachel Dancer (group lead)
Chris Bassford (grooup lead)