This multidisciplinary research area brings together researchers in platelet and endothelial cell biology and in leukocyte trafficking, spans from basic research on surface receptors, signalling pathways and gene regulation through to a variety of pathologies including thrombo-inflammatory disorders, platelet bleeding and cancer angiogenesis.
Birmingham-based researchers have uncovered several novel pathways of regulation of platelet activation including the collagen receptor complex, GPVI-FcR -chain, the Podoplanin receptor CLEC-2 and novel platelet inhibitory protein, G6b-B. They have developed unique in vitro models to study regulation of vascular endothelium, uncovering roles of stromal cells and flow in chronic inflammation and angiogenesis.
Novel lipid mediators controlling neutrophil recruitment have been discovered and studies of reverse neutrophil migration extended to murine models, suggesting that these cells may contribute to lung pathology. Studies on endothelium have also revealed novel genes and pathways regulating angiogenesis. Our research has also played a leading role in clinical trials changing clinical practice in peripheral vascular disease (BASIL trial).