This multidisciplinary research area brings together research in platelet signalling and function, leukocyte trafficking and endothelial cell biology, aiming to alleviate a variety of pathologies including thrombo-inflammatory vascular pathology, platelet function disorders and cancer angiogenesis, with major support from the British Heart Foundation.
Birmingham-based researchers have uncovered novel pathways controlling thrombosis and platelet formation, including signalling through the unique 'hemITAM' receptor CLEC-2, the platelet phosphatome and specific tyrosine phosphatases. They have also developed unique in vitro models to study regulation of vascular endothelium, uncovering roles of stromal cells and flow in chronic inflammation and angiogenesis.
Novel lipid mediators controlling neutrophil recruitment have been discovered and studies of reverse neutrophil migration extended to murine models, suggesting that these cells may contribute to lung pathology. Studies on endothelium have also revealed novel genes and pathways regulating angiogenesis. Our research has also played a leading role in clinical trials changing clinical practice in peripheral vascular disease (BASIL trial).