Metabolism and Bone Research Group

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Group leader: Dr Rachel Crowley

Overview

New to department as clinical researcher. Previous research and clinical interests include hypothalamic and pituitary disease, disorders of electrolyte and water balance, metabolic disease of bone. Planning to develop clinical endocrinology research at UoB in association with the UHB Trust, including database and biobank development, participation in multicentre UK and international clinical trials, initiation of translational studies.

Our research group

We are developing a research programme investigating the relationship between glucocorticoids and bone health, specifically glucocorticoid-induced osteoporosis and the role of pre-receptor metabolism of glucocorticoids in ageing bone. At UoB we are leading a trial of an 11b-HSD1 inhibitor in management of bone loss in post-menopausal women, which is based on previous work done in the department. Our work is done in collaboration with the team from the clinical metabolic bone disease service at UHB, and also includes phenotyping of rare genetic bone disorders and clinical research. Our Research Group is part of the MRC/ARUK Centre for Musculoskeletal Ageing, and collaborators include University of Sheffield and pharmaceutical industry partners.

Current Projects

  • Phase II study of the impact of AZD4017
  • A selective 11b-HSD1 inhibitor
  • On Biochemical markers of bone turnover in post-menopausal Osteopaenia

Recent Publications

Staff

Principal Investigator
Dr Rachel Crowley

Internal Collaborators
Dr Neil Gittoes
Dr Trevor Cole
Dr John Ayuk
Mr Kesavapilla Subramonian

External Collaborators
Professor Richard Eastell - University of Sheffield

Funding Bodies