The McCabe group focuses on basic and clinical aspects of thyroid disease and endocrine cancer. Specifically, we are engaged in cell, animal model (mouse) and human investigations into the actions of the proto-oncogenes PTTG and PBF in thyroid cancer and goitre, and in PBF function in breast, head and neck and colorectal cancer.
Improving radioiodine treatment of thyroid cancer. The efficacy of radioiodine treatment is central to clinical outcome in thyroid cancer. We are exploring a new way of modulating the ability of thyroid cells to uptake radioiodine.
The role of PTTG and PBF in genomic stability and DNA repair in thyroid cancer. The thyroid gland is sensitive to ionising radiation. Meanwhile, we have shown that PBF binds p53 and alters its functions. Therefore we are manipulating PBF and p53 in vitro and in vivo and examining responses to DNA damage.
PBF regulation of cell invasion and metastasis in thyroid and breast cancer. Having been the first to report that PBF induces cell invasion in breast cancer, we are investigating its role in migration, metastasis and invadopodia function.
Radioiodine treatment of breast cancer. We are manipulating PBF phosphorylation status to alter radioiodine uptake into breast cancer cells.
PTTG and PBF in head and neck cancer. In collaboration with Professor Hisham Mehanna we are mapping the expression and function of PTTG and PBF in oropharyngeal cancer.
The first reported mutation of the proto-oncogene PBF; its influence in thyroid cancer. The first de novo mutation of PBF has recently appeared within the COSMIC database; we are determining whether this experiment of nature has aetiological significance.
Molecular Genetic Investigation and Functional Analysis of non-RET Familial Medullary Thyroid Cancer. We are testing the functional significance of a novel mutation detected in a patient with MTC.
Read ML, Seed RI, Fong JC, Modasia B, Ryan GA, Watkins RJ, Gagliano T, Smith VE, Stratford AL, Kwan PK, Sharma N, Dixon OM, Watkinson JC, Boelaert K, Franklyn JA, Turnell AS and McCabe CJ (2014) The PTTG1-Binding Factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells. Endocrinology [Epub ahead of print]
Mehanna H, Carter B, Martin E, Watkinson JC, McCabe CJ, Boelaert K and Franklyn JA (2013) Differences in the recurrence and mortality outcome rates of incidental and non-incidental papillary thyroid microcarcinoma - A systematic review and meta-analysis of 21,329 person-years of follow-up. J Clin Endocrinol Metab [In Press]
Lewy GD, Ryan GA, Read ML, Fong JC, Poole V, Seed RI, Sharma N, Smith VE, Kwan PP, Stewart SL, Bacon A, Warfield A, Franklyn JA, McCabe CJ and Boelaert K (2013) Regulation of Pituitary Tumor Transforming Gene (PTTG) Expression and Phosphorylation in Thyroid Cells. Endocrinology 154(11):4408-22
Smith VE, Sharma N, Watkins RJ, Read ML, Ryan GA, Kwan PP, Martin A, Watkinson JC, Boelaert K, Franklyn JA and McCabe CJ (2013) Manipulation of PBF/PTTG1IP phosphorylation status; a potential new therapeutic strategy for improving radioiodine uptake in thyroid and other tumors. J Clin Endocrinol Metab 98(7):2876-86
Smith VE, Read ML, Turnell AS, Sharma N, Lewy GD, Fong JC, Seed RI, Kwan P, Ryan G, Mehanna H, Chan SY, Darras VM, Boelaert K, Franklyn JA and McCabe CJ (2012) PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8. Endocrinology 153(7):3526-36
Read ML, Lewy GD, Fong JC, Sharma N, Seed RI, Smith VE, Gentilin E, Warfield A, Eggo MC, Knauf JA, Leadbeater WE, Watkinson JC, Franklyn JA, Boelaert K and McCabe CJ (2011) Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment. Cancer Res 71(19):6153-64
Professor Chris McCabe - Schoool of Clinical and Experimental Medicine
Dr Kristien Boelaert - School of Clinical and Experimental Medicine
Dr Martin Read - School of Clinical and Experimental Medicine
Dr Vicki Smith - School of Clinical and Experimental Medicine
Mr Neil Sharma
Vikki Poole - MRC DTG PhD Student
Bhavika Modasia - Wellcome Trust PhD Student
Perkin Kwan - Wellcome Trust PhD Student
Waraporn Imruetaicharoenchoke - Siriraj Medical School, Bangkok, PhD Student