Study of Longterm Outcomes in Imprinting Disorders (SOLiD)

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Group leader: Dr Renuka Dias


Many imprinting disorders are characterised by abnormal growth, both in fetal and postnatal life. However the long-term health outcomes are unknown. We aim to undertake detailed research in people diagnosed with imprinting disorders from childhood into adulthood to better understand the risks to long-term health and the underlying mechanisms.

We are working in partnership with other clinicians across the UK to improve the overall care for children and adults with imprinting disorders.

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Our research group

Abnormal fetal growth has been linked to a number of metabolic diseases in adulthood, particularly Type 2 diabetes and cardiovascular disease (e.g. hypertension). Imprinting disorders are often associated with abnormal growth both pre-natally and post-natally. However, a link with adult disease is not well documented. The SOLiD team are interested in:

  • The epigenetics of imprinting disorders
  • The long-term health outcomes of imprinting disorders
Photograph of SOLiD Nursing Team

Current Projects

Our current research projects include an NIHR Portfolio Study (UKCRN ID 13914) in Silver-Russell Syndreme (SRS) and Beckwith-Wiedemann Syndrome (BWS). This study is looking at

  • novel genes involved to try and improve diagnosis rates in SRS
  • aspects of Growth and Development
  • the risk of developing other conditions (such as Type 2 diabetes)

Recent Publications


Principal Investigator
Dr Renuka Dias ( - School of Clinical and Experimental Medicine

Internal Collaborators
Professor Tim Barrett - School of Clinical and Experimental Medicine

NHS Collaborators
Kayleigh Aston - Study Co-ordinator, University Hospitals Birmingham NHS Trust, UK
Wendy Donoghue - Research Nurse, University Hospitals Birmingham NHS Trust, UK

External Collaborators
Professor Eamonn Maher - University of Cambrige