Respiratory Health

Group leads:

Peymane Adab and Jon Ayres

Overview

This multidisciplinary research group focuses on COPD, within a broader setting of respiratory epidemiology. Our research integrates the epidemiology of COPD, its management in primary care and translational research. The aim is to advance understanding of COPD and improve care and outcomes through linked studies and systematic reviews. There is also work on occupational asthma and smoking.

Our Research Group

Within this overall theme, ongoing work includes research on:

1) The epidemiology and natural history of COPD
2) Identification of risk factors for COPD
3) Approaches to early detection and screening for undiagnosed COPD
4) Improving our understanding of prognostic factors, particularly those that are modifiable, in relation to COPD
5) Development and evaluation of interventions in early COPD
6) Improving our understanding of work, employment and COPD and the relationships between disease factors and productivity (absenteeism and presenteeism)
7) Self-management in COPD
8) Use of non-invasive ventilation in COPD
9) Musculoskeletal changes in COPD

We have a particular interest in community based cohort studies and randomised controlled trials, as well as systematic reviews as methodologies for our research.

Current Projects...

COPD in primary care: from case finding to improving patient outcomes. Funder – NIHR Programme grant

The cost-effectiveness of community based non-invasive ventilation (NIV) in patients with stable end stage COPD with hypercapnic respiratory failure. A systematic review and economic evaluation. Funder – NIHR HTA

Supported self-management for patients with moderate to severe chronic obstructive pulmonary disease (COPD): an evidence synthesis and economic analysis. Funder – NIHR HTA

Patient self-management in primary care patients with COPD; a randomised controlled trial. Funder – NIHR National Schools of Primary Care

A pilot study to assess the prevalence and characteristics of emphysematous lung change in patients with symptoms of COPD and normal spirometry. Funder – NIHR National Schools of Primary Care

Evaluation of microspirometers as a screening test for case finding for COPD in primary care. Funder – NIHR National Schools of Primary Care

Risk stratification tool for COPD case finding (doctoral research fellowship). Funder - NIHR

Epidemiology of COPD within the Guangzhou Biobank Cohort Study. Funder - Guangzhou City Government.

Publications...

Telemonitoring for patients with COPD. R Jordan, P Adab, K Jolly. BMJ 2013 In Press

Case finding for chronic obstructive pulmonary disease in primary care: a pilot randomised controlled trial. S Haroon, P Adab, C Griffin, R Jordan. British Journal of General Practice, 2013; 63(606):e55-e62.

Past dust and gas/fume exposure and COPD in Chinese: The Guangzhou Biobank Cohort Study. KHB Lam, P Yin, CQ Jiang, WS Zhang, P Adab, MR Miller, GN Thomas, JG Ayres, TH Lam, KK Cheng. Respiratory Medicine 2012; 106(10):1421–1428

Sex, smoking and Chronic Obstructive Pulmonary Disease: the effect of different diagnostic criteria. Analysis of the Health Survey for England. RE Jordan, MR Miller, HKB Lam, KK Cheng, P Adab. Thorax 2012;67:600-605.

RE Jordan, KBH Lam, KK Cheng, MR Miller, JL Marsh, JG Ayres, D Fitzmaurice, P Adab. Case finding for chronic obstructive pulmonary disease: a model for optimising a targeted approach. Thorax 2010 65: 492-498

Staff...

PI(s): Rachel JordanJon AyresKate JollyKK Cheng

Other investigators: Sue JowettRichard RileySheila GreenfieldJen Marsh; Martin
Miller; Amanda Daley; Robert Stockley; David MooreHubert Lam; Steve Sadhra

Postdocs: Nicola Heneghan

Research staff: Alex Enocson; Andy Dickens; Joanne O’Beirn-Elliman; Deirdre O’Brien, Nicola Adderley; Saimma Majothi; Janine Dretzke, Amanda Farley

Students: Shamil Haroon; Kiran Kalirai; Halima Buni