Steroid Action and Human Disease is a major focus of CEDAM research. Over recent years we have combined unique capability for steroid metabolome analysis, using state-of-the-art mass spectrometry technology, with in vitro and in vivo models, underpinned by major funding from MRC, Wellcome, BBSRC and EU.
This integrated approach has been systematically applied to the understanding of mechanisms underlying both rare disorders and common disease such as obesity, diabetes, hypertension, polycystic ovary syndrome and chronic inflammation.
This has yielded discoveries of major relevance to human disease, including the identification of novel monogenic disorders resulting in impaired glucocorticoid activation and altered sex steroid activation. Our work has uncovered that ageing enhances glucocorticoid activation in the skin and its reversal results in improved wound healing.