Group leads: Professor David Adams, Prof Jane Mckeating, Dr Phil Newsome, Dr Patricia Lalor, Dr Bertus Eksteen, Dr Simon Afford, Dr David Mutimer
The 7 PIs based in the Centre for Liver Research are closely integrated with the internationally renowned Liver Transplant Unit at University Hospitals Birmingham NHS Foundation Trust. The close integration with the Hepatitis C virology group brings together expertise in the molecular biology of HCV infection and liver immunology to address the immunopathogenesis of HCV infection. The award of an NIHR Biomedical Research Unit for Cell and Immunotherapy of liver disease is allowing the Centre to translate its basic research programmes in immune mechanisms in liver disease and the molecular pathogenesis of hepatitis C infection into novel therapies.
Current translational programmes include:
the use of tissue-specific regulatory T cells to suppress inflammation
novel strategies to modulate effector cell recruitment
stem cell therapy to promote liver repair
adoptive immunotherapy with dendritic cells to stimulate protective immune responses against hepatitis C infection and liver cancer
the use of novel inhibitors of viral receptors to prevent recurrent HCV infection after liver transplantation.
Research group staff members...
Professor David Adams (group lead)
Professor of Hepatology and Director NIHR BRU Centre for Liver Research
Prof Jane Mckeating (group lead)
Professor of Molecular Virology
Dr Phil Newsome (group lead)
Senior Lecturer in Hepatology and Clinical Director of the Birmingham University Stem Cell Centre
Dr Patricia Lalor (group lead)
Dr Bertus Eksteen (group lead)
MRC Clinician Scientist/ Honorary Consultant Hepatologist
Dr Simon Afford (group lead)
Dr David Mutimer (group lead)
Reader in Hepatology and Honorary Consultant Hepatologist
LI Ka Kik
Wellcome Trust Clinical Research Fellow and Honorary SpR in Hepatology