Group leads: Professor David Adams, Prof Jane Mckeating, Prof Phil Newsome, Dr Patricia Lalor, Dr Simon Afford, Prof David Mutimer
The 7 PIs based in the Centre for Liver Research are closely integrated with the internationally renowned Liver Transplant Unit at University Hospitals Birmingham NHS Foundation Trust. The close integration with the Hepatitis C virology group brings together expertise in the molecular biology of HCV infection and liver immunology to address the immunopathogenesis of HCV infection. The award of an NIHR Biomedical Research Unit for Cell and Immunotherapy of liver disease is allowing the Centre to translate its basic research programmes in immune mechanisms in liver disease and the molecular pathogenesis of hepatitis C infection into novel therapies.
Current translational programmes include:
the use of tissue-specific regulatory T cells to suppress inflammation
novel strategies to modulate effector cell recruitment
stem cell therapy to promote liver repair
adoptive immunotherapy with dendritic cells to stimulate protective immune responses against hepatitis C infection and liver cancer
the use of novel inhibitors of viral receptors to prevent recurrent HCV infection after liver transplantation.
Research group staff members...
Professor David Adams (group lead)
Dean, Professor of Hepatology and Director NIHR BRU Centre for Liver Research
Prof Jane Mckeating (group lead)
Professor of Molecular Virology
Dr Phil Newsome (group lead)Professor of Experimental Hepatology and Clinical Director of the Birmingham University Stem Cell Centre
Dr Patricia Lalor (group lead)
Non-Clinical senior lecturer
Dr Simon Afford (group lead)
Reader in Liver Immunobiology
Prof David Mutimer (group lead)
Professor of Clinical Hepatology and Honorary Consultant Hepatologist
Ye Htun Oo