Inflammation Biology

Inflammation research has now coalesced around interdisciplinary Centres of excellence such as the Centre for Translational Inflammation Research (CTIR) and the Centre for Liver Research.  We aim to identify shared biological mechanisms that define the functional features of chronic inflammatory disease by integrating disease specific expertise. Our work co-locates basic and clinical scientists working on inflammation in the joints, liver, lung, eye and kidney and in trauma. 

We work closely with the new Queen Elizabeth Hospital at Birmingham and the Centre for Defence Medicine.  They provide outstanding facilities and patient cohorts.  We study immune mediated inflammatory disease, resolution of inflammation, inflammageing and trauma.  This work is supported by infrastructure funding from key funders that has supports capital investment, staff and PhD programmes.  Our aim is to build capacity in this area and to foster collaboration between basic scientists and clinical academics.  Our focus on common processes underlying chronic inflammatory disease has led to new insights into mucosal inflammation, rheumatoid arthritis and spondylarthropathies.  Our work on inflammageing ,  focussing  on age-related systemic inflammation and pathology,  is demonstrating that inflammageing and autoimmunity are driven by immune senescence rather than by latent infections such as cytomegalovirus.

 Our main research themes in this area are:-

  • Inflammatory Liver disease supported by the NIHR Liver Biomedical Resource Centre  (BRU)
  • Rheumatology supported by the ARUK Centre of Excellence for Pathogenesis
  • Musculosketal Ageing supported by the MRC - Arthritis Research UK Centre for Musculoskeletal Ageing Research (CMAR)
  • Trauma supported by the NIHR Surgical Reconstruction and Microbiology Research Centre (NIHR SRMRC)
  •  Inflammageing  

Understanding ageing and its influence on health remains a national strategic priority, and there has been significant local investment in ageing biology to integrate groups already working in this area through the formation of the multi-disciplinary Centre for Healthy Ageing Research. Future sustainability and strength of this area was demonstrated by funding of an MRC-ARUK Centre in Musculoskeletal Ageing Research , a partnership with Nottingham University, spanning across the Centre for Translational Inflammation Research and Endocrinology with links to the Schools of Sport, Exercise and Rehabilitation Sciences and Psychology.