Gene-Rad-Risk is an international collaborative study of the joint influences of radiation and genotype on breast cancer risk and is funded by the European Union under the 6th Framework Programme.
The main objective of the study is to test whether mutations or polymorphisms in specific DNA repair genes, which were also associated with an increased risk of breast cancer, increase the risk of radiation induced breast cancer. In addition to studying the possible interactions between radiation exposure and genes, a secondary objective will be to study the possible modifying effects of reproductive factors and cancer therapies other than radiation on the risk of radiation induced breast cancer. The Centre for Childhood Cancer Survivor Studies organizes the British part of the study which involves approximately 350 female adult survivors of childhood cancer. More information can be found in the study documents which can be viewed and downloaded below.
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