Groups involved

Team1  

University of Birmingham...

Lead Scientist:
Prof. Thomas Dietrich

Other Researchers:
Prof. Christopher D. Buckley
Prof. Iain L.C. Chapple 
Dr Helen J Cooper
Prof. Paul R. Cooper 
Dr Melissa Grant
Dr Paola de Pablo
Dr. Dagmar Scheel-Toellner

RAPID Fellow(s):
Stefan Serban

Description of Research:
Research Roles within RAPID: Biomarker studies in cohorts of patients with RA +/- PD
Shared PD/RA auto-antigens & tolerance breakdown due to NETs/citrullination

Karolinska Institutet...

Lead Scientist:
Dr Karin Lundberg

Other Researchers:
Dr Tulay Lindberg

RAPID Fellow(s):
Natalya Sherina

Description of Research:
Cellular and molecular immunology of RA, related to peridontitis

Roles within RAPID:
Biomarker Studies in cohorts of patients with RA +/- PD
Shared PD/RA auto-antigens & tolerance breakdown due to NETs/citrullination
Project integration: bioinformatics

Uniwersytet Jagielloński...

Lead Scientist:
Prof. Jan Potempa

Other Researchers:
Dr. Joanna Koziel Joanna.koziel@uj.edu.pl
Dr. Malgorzata Benedyk malgorzata.benedyk@uj.edu.pl
Dr. Danuta Mizgalska danuta.mizgalska@uj.edu.pl
Dr. Tomasz Kantyka
Mgr. Magdalena Nowak magdalena.lidia.nowak@uj.edu.pl
Mgr. Aneta Sroka aneta.sroka@uj.edu.pl

RAPID Fellow(s):
Alicia Wong

Description of Research:
Our investigations are focused on virulence pathways of bacterial pathogens, especially on the role of bacterial enzymes and proteins, among others proteases and peptidyloarginine deiminase, in the deregulation of a number of physiological pathways and evasion of host immunity. Our studies centre on Staphylococcus aureus and periodontal pathogens, including Porphyromonas gingivalis, Prevotella intermedia and Tannerella forsythia. The present studies are also aimed at elucidation of a novel protein secretion system (PerioGate) used by periodontopathogens to secrete they virulence factors, including proteinases.

Roles within RAPID:
Structural characterisation of PADs and other proteins of therapeutic interest
Shared PD/RA auto-antigens & tolerance breakdown due to NETs/citrullination
Animal models of PD and RA to study therapeutic effects

Charité – Universitäts medizin Berlin (Humboldt Universität zu Berlin)...

Lead Scientist:
Prof. Dr. Frank Buttgereit frank.buttgereit@charite.de
Dr Jacqueline Detert jacqueline.detert@charite.de 
PD Dr. Nicole Pischon nicole.pischon@charite.de, Dept. Periodontology

Other Researchers:
Vera Höhne-Zimmer vera.hoehne-zimmer@charite.de
Anja Pfadenhauer anja.pfadenhauer@charite.de

RAPID Fellow(s):
Leonor Santos 
Katarzyna Gurzawska

Description of Research:

Roles within RAPID:
Biomarker Studies in cohorts of patients with RA +/- PD
Shared PD/RA auto-antigens & tolerance breakdown due to NETs/citrullination

Deutsches Institut für Ernährungsforschung...

Lead Scientist:
Prof. Heiner Boeing boeing@dife.de

Other Researchers:

RAPID Fellow(s):
KoladeOluwagbemigun

Description of Research:

Roles within RAPID:
Biomarker Studies in cohorts of patients with RA +/- PD

Shared PD/RA auto-antigens & tolerance breakdown due to NETs/citrullination

Project integration: bioinformatics

Aston University, (ASTON), UK...

Lead Scientist:
Prof. Helen Griffiths
 
Other Researchers:

RAPID Fellow(s):
Rita Carilho

Description of Research:

Roles within RAPID:
Post-translational Modifications (PTMs) of proteins and their role in RA/PD

Shared PD/RA auto-antigens & tolerance breakdown due to NETs/citrullination

Agenica Estatal Consejo de Investigaciones Cietifica...

Lead Scientist:
Prof. F. Xavier Gomis-Ruth fxgr@ibmb.csic.es
(Lab homepage - www.ibmb.csic.es/home/xgomis)
Prof. Maria Solà fxgr@ibmb.csic.es
(Lab homepage - http://www.ibmb.csic.es/home/msola)

Other Researchers:

RAPID Fellow(s):
Arka Chakraborty
Rosanna Caliandro – Completed Fellowship

Description of Research:
Structural characterisation of PADs and other proteins of therapeutic interest

Roles within RAPID:
Structural characterisation of PADs and other proteins of therapeutic interest

University of Glasgow...

Lead Scientist:
Prof. Iain McInnes

Other Researchers:
Prof. Paul Garside
Dr Shauna Culshaw

RAPID Fellow(s):
Ana Adrados Planell

Description of Research:
Murine periodontal disease models will be employed to assess if P. gingivalis infection exacerbates RA. The potential influence of oral inflammation on systemic autoimmunity and inflammation will be investigated using transgenic animals and bacteria with molecular and cellular analysis. In addition, comparison of P. gingivalis W83 or PPAD deficient mutant will indicate whether PPAD modulates the autoimmune response.

Roles within RAPID:
Biomarker Studies in cohorts of patients with RA +/- PD

Post-translational Modifications (PTMs) of proteins and their role in RA/PD

Animal models of PD and RA to study therapeutic effects

Anaxomics Biotech S.L...

Lead Scientist:
Dr. Judith Farres Marisch info@anaxomics.com

Other Researchers:

RAPID Fellow(s):
Florian Boulnois

Description of Research:
The Anaxomics team possesses a long-time experience in clinical research, computational science, biotechnology and systems biology coming both from the private sector and from the leading research institutions in Spain. The R&D department counts on 4 principal investigators, 3 bachelors and 4 technicians. The Scientific Advisory Board includes renowned scientists in the field of Systems Biology and Drug Discovery: P. Aloy, PhD (ICREA Research Professor and Researcher at the Structural Bioinformatics Lab at IRB Barcelona) and J. Bigorra MD, PhD, (Director of Innovation at the Hospital Clínic de Barcelona).

Roles within RAPID:
Biomarker Studies in cohorts of patients with RA +/- PD

Project integration: bioinformatics

Protein interaction network generation and analysis for PD and RA. Translate the system understanding into novel drug discovery strategies. Identify variables that best measure risk or protective factors and can be followed in prospective studies.

Imagen Biotech Ltd....

Lead Scientist:
Dr. Gareth Griffiths Gareth.griffiths@imagen-biotech.com

Other Researchers:

RAPID Fellow(s):
Ilaria Jessica Chicca

Description of Research:
Phenotypic and high content screening

Roles within RAPID: Biomarker Studies in cohorts of patients with RA +/- PD

Shared PD/RA auto-antigens & tolerance breakdown due to NETs/citrullination
Animal models of PD and RA to study therapeutic effects

Ernst Moritz Arndt University of Greifswald...

Lead Scientist:
Mr. Thomas Kocher kocher@uni-greifswald.de  
http://www.dental.uni-greifswald.de/

Other Researchers:
Ms. Birte Holtfreter birte.holtfreter@uni-greifswald.de

RAPID Fellow(s):
Yiqiang Zhan

Description of Research:
Epidemiological aspects of periodontal diseases and relations between periodontitis and systemic diseases

Roles within RAPID:
Biomarker Studies in cohorts of patients with RA +/- PD

Shared PD/RA auto-antigens & tolerance breakdown due to NETs/citrullination

Unilever R&D Vlaadingen...

Lead Scientist:
Rachel Newson

Other Researchers: 
Dr. Ann Scott
Dr. Melanie Brading

RAPID Fellow(s):
Dr. Geng Zong

Description of Research: 
Evaluating the association between diet, RA and PD in prospective cohort studies (e.g., SHIP and EPIC-Potsdam)

Roles within RAPID: 
Work Package 1 (Biomarker Studies in cohorts of patients with RA +/- PD) & WP 6 (Project integration: bioinformatics)

Oxford University...

Lead Scientist:
Prof. Patrick J. Venables p.venables@imperial.ac.uk

Other Researchers: 
Anne-Marie Quirke
Elena Lugli
Anna Montgommery

RAPID Fellow(s):
Raquel Correia

Description of Research: 
P gingivalis In the aetiology of RA

Roles within RAPID:
Biomarker Studies in cohorts of patients with RA +/- PD

Post-translational Modifications (PTMs) of proteins and their role in RA/PD

Structural characterisation of PADs and other proteins of therapeutic interest

Shared PD/RA auto-antigens & tolerance breakdown due to NETs/citrullination

University of Bergen, Norway...

Lead Scientist:
Dr. Piotr Mydel piotr.mydel@gades.uib.no

Other Researchers:
Ms. Annelie Hellvard

RAPID Fellow(s):
Catalin Koro

Description of Research:

Roles within RAPID:
Post-translational Modifications (PTMs) of proteins and their role in RA/PD

Shared PD/RA auto-antigens & tolerance breakdown due to NETs/citrullination

Animal models of PD and RA to study therapeutic effects

RAPID ESR:
Ms. Catalin Koro

 

Team2

 

 

EU Flag

Project number: RAPID - 290246