Current trials

Current trials

Please see below the trials currently being run (recruiting or in follow up) at the BCTU. Follow the links for more information:

Coloproctology

  • ACCURE-UK: The feasibility of undertaking Appendicectomy to impact upon the Clinical Course of UlceRativE colitis
  • CReST: The role of endoluminal stenting in the acute management of obstructing colorectal cancer
  • DREAMS: Deaxamethasone Reduces Emesis After Major gastrointestinal Surgery
  • ElaTION: The Efficacy and Cost effectiveness of Real Time Ultrasound Elastography in The Investigation Of Thyroid Nodules and the diagnosis of thyroid cancer
  • ENDCaP-C: Enhanced Neoplasia Detection and Cancer Prevention in Chronic Colitis
  • FIAT: The Fistula-In-Ano Trial comparing Surgisis® anal fistula plug versus surgeon’s preference for transsphincteric fistula-in-ano
  • FOxTROT: Fluoropyrimidine, OXaliplatin and Targeted-Receptor pre-Operative Therapy for patients with high-risk, operable colon cancer
  • PROSPER: PROlapse Surgery: PErineal or Rectopexy
  • ROCSS: Reinforcement of Closure of Stoma Site. A randomised controlled trial of reinforcement of closure of stoma site using a biological mesh.
  • TREC: Transanal Endoscopic Microsurgery (TEM) and Radiotheraphy in Early Rectal Cancer

Neurosciences

  • IIH:DT: A placebo controlled double blind randomised trial of AZD4017 for the treatment of Idiopathic Intracranial Hypertension.
  • IIH:WT: A randomised controlled trial of bariatric surgery versus a community weight loss programme for the sustained treatment of Idiopathic Intracranial Hypertension.
  • PD COMM: A full scale randomised controlled trial on the effectiveness and cost-effectiveness of speech and language therapy for people with Parkinson's.
  • PD COMM Pilot: A pilot to evaluate the feasibility of a full scale trial on the effectiveness and cost-effectiveness of speech and language therapy for people with Parkinson's.
  • PD GEN: A Parkinson's disease DNA Bank.
  • PD MED: A large randomised assessment of the relative clinical- and  cost-effectiveness of classes of drugs for Parkinson's disease.
  • PD REHAB: A randomised controlled trial to assess the clinical- and cost-effectiveness of Physiotherapy and Occupational Therapy in Parkinson's disease.
  • PD SURG: A large randomised assessment of the relative clinical- and cost-effectiveness of surgery for Parkinson's disease.

Portfolio V (Developing Theme; cardio, vascular, trauma)

  • BASIL-2: The Bypass versus Angioplasty in Severe Ischaemia of the Leg-2 Trial.
  • BASIL-3: Balloon vs Stenting in Severe Ischemia of the Leg-3 Trial.
  • PEGASUS: A feasibility and open pilot two-arm randomised controlled trial comparing Pressure Garment Therapy with No Pressure Garment Therapy for the prevention of abnormal Scarring after burn injury.
  • RATE-AF: RAte control Therapy Evaluation in permanent Atrial Fibrillation. Evaluating different rate control therapies in permanent atrial fibrillation: A prospective, randomised, open-label, blinded endpoint study comparing digoxin ans beta-blockers as initial rate control therapy.
  • RePHILL: Resuscitation with pre-hospital blood products. A multi-centre randomised controlled trial of pre-hospital blood product administration versus standard care for traumatic haemorrhage.
  • SPIRO-CKD: A randomised, multicentre, open-label, blinded endpoint trial to compare the effects of Spironolactone to Chlortalidone on left ventricular mass and arterial stiffness in stage 2 and stage 3 chronic kidney disease.
  • TOPIC: A Randomised Controlled Trial to investigate the effectiveness of Thoracic Epidural and Paravertebral Blockade in reducing Chronic Post-Thoracotomy Pain

Primary Care

  • ASPIRE -  A study promoting the influenza response in the elderly
  • BAFTA - Birmingham Atrial Fibrillation Treatment of the Aged (BAFTA) Follow-up Study
  • CREDIBLE - ColoRectal Early Diagnosis: Information Based Local Evaluation
  • ExACT - Extended anticoagulation treatment for VTE: a randomised trial
  • EXTOD - Examining the barriers and benefits of exercise in type 1 diabetes mellitus
  • HEAT - Helicobacter eradication to prevent ulcer bleeding in aspirin users: a large simple randomised controlled trial
  • POLYPILL  
  • REFER - (REFer for EchocaRdiogram) - A Prospective Validation of a Clinical Decision Rule, NT-proBNP, or their combination, in the Diagnosis of Heart Failure in Primary Care

Renal

  • ASTRAL: Angioplasty and STent for Renal Arterial Lesions
  • eGFR-C: Accuracy of glomerular filtration rate (GFR) estimation using creatinine and cystatin C and albuminuria for monitoring disease progression in patients with stage 3 chronic kidney disease: prospective longitudinal study in a multi-ethnic population.
  • PEXIVAS: An international randomised controlled trial of plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis
  • PREDNOS: Long-term tapering versus standard prednisolone (steroid) therapy for the treatment of the initial episode of childhood nephrotic syndrome: a national multicentre randomised double blind trial
  • PREDNOS 2: Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome; the PREDNOS 2 study
  • STOP-ACEi: A multi-centre randomised controlled trial of Angiotensin Converting Enzyme inhibitor (ACEi) / Angiotensin Receptor Blocker (ARB) withdrawal in advanced renal disease

Women's health

  • ABA: Assets-based feeding help Before and After birth (ABA): feasibility study for improving breastfeeding initiation and continuation
  • BUS: Accuracy of Bladder Ultrasound (BUS) in the diagnosis of Detrusor Overactivity (DO): a study to evaluate if ultrasound can reduce the need for urodynamics
  • C-STICH: Cerclage suture type for an Insufficient cervix and its effect on health outcomes trial: a randomised controlled trial of monofilament versus braided sutures for insufficient cervix
  • FEMME: An NIHR funded clinical trial designed to measure the changes in the quality of life women experience when their fibroids are treated by either myomectomy or uterine artery embolisation
  • GAPP2: A multi-centre, double-blind randomised controlled trial of the efficacy and mechanism of action of gabapentin for the management of chronic pelvic pain in women
  • GEM3: A double blind, placebo-controlled trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy
  • GBS2: Accuracy of a rapid intrapartum test for maternal group B streptococcal colonisation and its potential to reduce antibiotic usage in mothers with risk factors
  • HOLDS: High or Low Dose Syntocinon® for delay in labour
  • LOTUS: Local Oestrogen Treatment in Postmenopausal Women Undergoing Pelvic Organ Prolapse Surgery (LOTUS): A Feasibility Study
  • MEDAL: A diagnostic accuracy study investigating whether MRI scans can replace or triage the use of laparoscopy in establishing a diagnosis amongst women presenting in secondary care with chronic pelvic pain
  • Pre-empt:Preventing Recurrence of Endometriosis by Means of long acting Progestogen Therapy
  • PRISM: The effectiveness of progesterone to prevent miscarriage in women with early pregnancy bleeding: a randomised placebo controlled trial
  • RESPITE: A Randomised Controlled Trial of Remifentanil intravenous patient controlled analgesia (PCA) versus intramuscular pethidine for pain relief in labour
  • TABLET: Randomised controlled trial of the efficacy and mechanism of levothyroxine treatment on pregnancy and neonatal outcomes in women with thyroid antibodies
  • UCON: Ulipristal acetate versus conventional management of heavy menstrual bleeding (HMB; including uterine fibroids): a randomised controlled trial and exploration of mechanism of action

Other trials

  • AML 16: National Cancer Research Institute Acute Myeloid Leukaemia and High Risk MDS: a trial programme for treatment development for older patients with Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome.
  • ROCkeTS: Refining Ovarian Cancer Test Accuracy Scores: A test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer.