Please note that the ASTRAL trial and its associated sub-studies closed to recruitment in October 2007.
Obtain patient consent.
Prepare for telephone questions using the randomisation notepad.
Note: The person randomising will need to answer all questions on the randomisation notepad.
Ring the randomisation service on 0800 953 0274 (toll-free).
When all the relevant questions on the randomisation notepad have been answered, a treatment allocation and patient reference number will be given.