For trial participants

aspirin-bottle

Who can enter: You may be able to take part in this trial if you are 60 years of age or older and are taking aspirin at a dose of 325mg per day or lower.

Who can’t enter:

You will not be able to take part in this trial if:

  • You are currently taking anti-ulcer therapy (e.g. H2-receptor antagonists and proton-pump inhibitors).
  • You are taking non-steroidal anti-inflammatory drugs (NSAIDs).
  • You have an intolerance or allergy to H. pylori eradication treatment.
  • You are taking certain drugs that may interact with the trial medication.
  • You are terminally ill or suffer from a life-threatening illness.
  • You are currently participating in another interventional clinical trial, or have taken part in a trial in the previous three months.

Tests and treatments: Potentially eligible patients will be invited to a screening appointment at their GP practice. They will be asked to fast, and not smoke, for 6 hours prior to this visit.

Inclusion/exclusion criteria will be checked and the patient consented by an appropriately trained research nurse. Following consent the research nurse will perform a brief assessment, including blood pressure measurement and demographics. The patient will perform a breath test to establish whether they carry the H. pylori infection in their stomach.

Patients will be told of the results of their breath test via the post, and if they tested positive they will receive trial medication (either eradication treatment or placebo) by post. Participants will continue to take aspirin at their prescribed dose.

Patients will not be required to attend any face-to-face follow-up visits. We will contact patients on an annual basis to ask them for information regarding any hospitalisations they have experienced in the previous year.