A Plethora of interacting organellar Ca2+ stores.
F. Michelangeli, O.A. Ogunbayo & L.L. Wootton (2005)
Current Opinions in Cell Biology 17, 135-140
Complex [Ca2+]i signals in human spermatozoa depend upon a Ca2+ store regulated by secretory pathway Ca2+-ATPase (SPCA1) Ca2+ pumps
C. Harper, L. Wootton, F. Michelangeli, L. Lefievre, C. Barratt, S. Publicover (2005)
J. Cell Science 118, 1673-1685
Calcium signalling in human spermatozoa: a specialized ‘toolkit’ of channels, transporters and stores.
C. Jimenez-Gonzalez, F. Michelangeli, C.V. Harper, C.L.R. Barratt & S.J. Publicover (2006)
Human Reproduction Update 12; 253-267
The effects of the phenylalanine 256 to valine mutation on the sensitivity of SERCA Ca2+ pump isoforms: 1, 2 & 3 to thapsigargin and other inhibitors
L.L. Wootton & F. Michelangeli (2006)
Biol. Chem. 281; 6970-6976
Understanding the physiology of pre-fertilization events in the human spermatozoa- a necessary prerequisite to developing rational therapy
S.J. Conner, L. Lefievre, J. Kirkman-Brown, F. Michelangeli, C. Jimenez-Gonzalez, G.S.M. Macchado-Oliveirea, K.L. Pixton, I.A. Brewis, C.L.R. Barrat & S.J. Publicover (2007)
Soc. Reprod. Fertil. Suppl. 63; 237-255
The interactions of the brominated flame retardant: Tetrabromobisphenol A with phospholipid membranes
O.A. Ogunbayo, K.T. Jensen, F. Michelangeli (2007)
Biochimica et Biophysica Acta 1768; 1559-1566
The brominated flame retardant, tetrabromobisphenol A, inhibits SERCA Ca2+ pumps and sensitizes the Ryanodine receptor
O.A. Ogunbayo, H. Ho Tin Wu, F. Michelangeli (2007)
Proceedings Physiol. Soc. Life Sciences; PC 270
The effects of tetrabromobisphenol-A, a brominated flame retardant, on Ca2+ signalling and cell viability in Sertoli cells
P.F. Lai, O.A. Ogunbayo, T.J. Connolly, F. Michelangeli (2007)
Proceedings Physiol. Soc. Life sciences; PC271
The widely utilized brominated flame retardant, tetrabromobisphenol A (TBBPA) is a potent inhibitor of the SERCA Ca2+ pump.
O.A. Ogunbayo & F. Michelangeli (2007).
Biochemical Journal. 408; 407- 415
The brominated flame retardant, Tetrabromobisphenol-A (TBBPA), induces cell death in cultured Testicular TM4 Sertoli cells via a mechanism involving Ca2+ mobilization: TBBPA can affect both SERCA Ca2+ pumps and Ryanodine receptor Ca2+ channels.
O.A. Ogunbayo, P.F. Lai, T.J. Connolly & F. Michelangeli (2008)
Toxicology In-Vitro 22; 943-952
Endocrine disrupting alkylphenols: Structural requirements for their adverse effects on Ca2+ pumps, Ca2+ homeostasis & Sertoli TM4 cell viability.
F. Michelangeli, O.A. Ogunbayo, L.L. Wootton, P.F. Lai, F. Al-Mousa, R.M. Harris, R.H. Waring & C.J. Kirk. (2008)
Chemico-Biological Interactions 176; 220-226
Inhibition of the sarcoplasmic / endoplasmic reticulum Ca2+-ATPase (SERCA) by flavonoids: A quantitative structure-activity relationship study.
O.A. Ogunbayo, R.N. Harris, R.H. Waring, C.J. Kirk & F. Michelangeli (2008)
IUBMB-Life 60; 853-858
The commonly used Ryanodine receptor activator, 4-chloro-m-cresol (4CmC), is also an inhibitor of SERCA Ca2+ pumps.
F. Al-Mousa and F. Michelangeli (2009)
Pharmacological Reports 61; 838-842
Dual mechanism of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria.
D. Hermanson, S,N. Addo, A.A. Bajer, J.S. Marchant, S. Goutam, K. Das, B. Srinivasan, F. Al-Mousa, F. Michelangeli, D.D. Thomas, T.W. LeBien, C. Xing (2009)
Molecular Pharmacology 76; 667-678
Changes in expression and activity of the secretory pathway Ca2+ ATPase 1 (SPCA1) in A7r5 vascular smooth muscle cells, cultured at different glucose concentrations.
P. Lai and F. Michelangeli (2009)
Bioscience Reports 29; 397-404
Ca2+-stores in sperm: their identities and functions.
S. Costello, F. Michelangeli , K. Nash, L. Lefievre, C. Ford, J. Morris, G. Machado-Oliveira, J. Kirkman-Brown, S. Publicover. (2009)
Reproduction 138; 425-437
Alisol B is a novel inhibitor of the SERCA pump that induces autophagy, ER-stress and apoptosis
B.Y.K. Law, M. Wang, E. Ma, F. Al-Mousa, F. Michelangeli, A. Wong, M. Ng, K. To, A.Y.F. Mok, S.K. Lam, F. Chen, C. Che, P. Chiu, B.C.B. Ko. (2010)
Mol Cancer Therapeutics 9; 718-730
A Diversity of SERCA Ca2+ pump Inhibitors
F. Michelangeli & J.M. East (2011)
Biochemical Society Transactions 39; 789-797
Recent advances in membrane biochemistry
J.M. East & F. Michelangeli (2011)
Biochemical Society Transactions 39; 703-709
Regucalcin (RGN/SMP30) alters agonist- and thapsigargin-induced cytosolic [Ca2+] transients in cells by increasing SERCA Ca2+ATPase levels
P. Lai & F. Michelangeli (2011)
FEBS Letts 585, 2291-2294
Some commonly used brominated flame retardants cause Ca2+-ATPase inhibition, , beta-amyloid peptide release and apoptosis in SH-SY5Y neuronal cells
F. Al-Mousa & F. Michelangeli (2012)
PLOS One 7; e33059, 1-8
Bis(2-hydroxy-3-tert-butyl-5-methyl-phenyl)-methane (bis-phenol) is a potent and selective inhibitor of the secretory pathway Ca2+ ATPase (SPCA1)
P. Lai & F. Michelangeli (2012)
Biochem. Biophys. Res. Comm. 424; 616-619
Ca2+ signalling through CatSper and Ca2+ stores generates functional diversity in human sperm behavior.
S. Costello, W. Alasari, J. Correia, S.K. Oxenham, L. Fernandes, J. Kirkman-Brown,
F. Michelangeli, C. Barratt & S. Publicover
J. Biol Chem. (2013) 288; 6248-6258
Saikosaponin-d, a novel SERCA inhibitor induces autophagic cell death in apoptosis-defective cells.
VKW Wong, T Li, BYK Law, EDL Ma, NC Yip, F Michelangeli, CKM Law, MM Zhang,
KYC Lam, PL Chan, & L Liu
Cell Death & Disease (2013) 4; e720 doi 10.1038/cddis.2013.217
The sarcoplamsic-endoplasmic reticulum Ca2+-ATPase (SERCA) is the likely molecular target for the acute toxicity of the brominated flame retardant, hexabromocyclododecane (HBCD)
F. Al-Mousa & F. Michelangeli
Chemico-Biological Interactions (2014) 207; 1-6
Related flavonoids cause Cooperative inhibition of the the sarcoplasmic reticulum Ca2+ATPase by multimode mechanisms
O.A. Ogunbayo & F. Michelangeli
FEBS Journal (2014) (in press)