Brief research profiles of the key members of the team are included below, showing discipline and the keywords illustrative of their research on the physical sciences at the Life Sciences Interface.
Professor M Hannon (Director of the DTC)
Chemistry; molecular probe design; fluorescence; DNA recognition.
Professor E Claridge (Steering Committee)
Computer science; multispectral imaging, physics of image formation, quantitative fluorescence microscopy, biomedical image analysis, modelling.
Dr L Grover (Steering Committee)
Chemical engineering; bioresponsives, orthopaedic applications.
Professor L Macaskie (Steering Committee)
Biosciences; MRI biofilms; bioreactors, biomedical devices, ESEM biofilms, AFM biominerals, confocal microscopy biofilms, Proton Induced X-ray Emission (PIXIE) elemental mapping.
Professor G Nash (Steering Committee)
Medicine; haemodynamics, vascular biology, blood rheology.
Professor C Thomas (Steering Committee)
Biosciences; replication, stability, gene spread and global regulation of bacterial plasmids; polyketide antibiotic synthesis.
Professor D Walmsley (Steering Committee)
Dentistry; ultrasonics, bioeffects; imaging of vibration characteristics; biological effects of low-frequency (kHz) ultrasonic instruments.
Dr J Bunch (Mentor Panel)
Chemistry; mass spectrometry imaging; MALDI-MS; LA-ICP-MS; drug distribution studies.
Dr H Dehghani (Mentor Panel)
Computer science; physiological measurements; optical imaging; image reconstruction; molecular imaging.
Professor R Palmer
Physics; immobilisation of individual protein molecules with size-selected clusters, liquid phase atomic force microscopy, electrospray deposition of mass-selected protein beams.
Dr Z Pikramenou (Mentor Panel)
Chemistry; lanthanide fluorescent markers/labels; MRI contrast agents.
Dr J Rappoport
Biosciences; polarised trafficking in cell migration; clathrin-mediated endocytosis.
Dr I Styles (Mentor Panel)
Computer science; medical image analysis; biomedical optics; model-based image interpretation; computational modelling.
Dr S Thomas
Cardiorespiratory science; actin dynamics; megakaryocytes; visualising the dynamics of proteins in live platelets for study of the cytoskeleton; actin nodules.
Professor S Watson (Mentor Panel)
Cardiovascular sciences and cellular pharmacology; physiological and pathological features and roles of platelets in activation by glycoprotein receptors; actin polymerisation; angiogenesis; cancer metastasis; major organ dysfunction; stem cell recruitment.
Dr N Davies
Child health; functional Imaging and metabolomics of childhood cancer; magnetic resonance spectroscopy metabolite profiles for characterising childhood tumours.
Professor J Frampton
Stem cell biology; processes causing failures of stem cell regulation.
Professor J Heath
Biosciences; structure and function of growth factors and their receptors.
Dr N Hodges
Biosciences; repair of oxidative DNA damage; mechanisms of secondary genotoxicity related to oxidative stress.
Professor Z Kourtzi
Psychology; multimodal brain imaging methods (structural and functional MRI, EEG, MEG); established behavioural paradigms and mathematical algorithms to study brain structure, neural function and behaviour.
Dr A Peet
Academic paediatrics and child health; magnetic resonance spectroscopy; magic angle spinning NMR; childhood brain tumours.
Professor L Young
Cancer sciences; different forms of EBV latency in virus-associated tumours; EBV gene expression in post-transplant lymphomas; Hodgkin’s lymphoma and nasopharyngeal carcinoma; signalling functions of EBV-encoded latent proteins.
Dr T Arvanitis
Electronic, electrical and computer engineering; biomedical internet engineering and patient records; medical imaging; complex computer software, networks and architectures.
Dr A Bagshaw
Psychology; EEG and fMRI to provide more precise spatial and temporal localisation of brain activity.
Professor R Beale
Computer science; theories of interaction; usability; mobile and pervasive computing; intelligent agents; genetic algorithms; neural networks; e-learning and HCI education.
Dr K Brain
Physiology and pharmacology of autonomic junctional transmission; confocal microscopy; electrophysiology; immunohistochemistry.
Dr M Britton
Chemistry; Nuclear Magnetic Resonance (NMR); Magnetic Resonance Imaging (MRI); oscillatory and autocatalytic reactions; chemical waves and patterns; magnetic field effects.
Dr S Brogna
Biosciences; RNA processing and translation.
Dr J Caamano
Immune regulation; roles of nuclear factor-kappa B (NF-kB) proteins in interactions between bone marrow derived cells and stromal cells at the core of secondary lymphoid tissue development.
Dr M Chechlacz
Dr M Chidgey
Cancer sciences; cancer cell biology; cardiovascular research; skin diseases; molecular basis of desmosomal adhesion.
Dr Y L Chiu
Metallurgy; microstructural details governing plasticity of advanced structural and functional materials.
Dr A Chowdhury
Dr P Cooper
Dentistry; tissue injury, repair and regeneration.
Dr A Filer
Inflammation and inflammatory disease; predictive and therapeutic approaches to the treatment of inflammatory arthritis including roles of stromal fibroblast cells in regulating the switch to persistence.
Professor P Fryer
Chemical engineering for the food industry including product safety assurance and palatability.
Dr A Hidalgo
Developmental neuro-plasticity; neurotrophins; glial cells.
Professor R Johnston
Chemistry; simulation of solids, surfaces and clusters; modelling cluster growth and dynamics; nanoalloy clusters; electronic structures of inorganic and organic solids.
Dr A Kaban
Computer science; statistical machine learning; data mining; high dimensional data spaces; probabilistic modelling of data; Bayesian inference.
Dr N Kahlia
Cardiovascular sciences; pathophysiological mechanisms underlying ischemia-reperfusion (I/R) injury including contributory roles of platelets.
Dr J Kirkman-Brown
Clinical and experimental medicine; calcium signalling; fluid dynamics.
Dr J Kreft
Biosciences; anaerobic demethylation; individual-based modelling of microorganisms.
Dr N Krone
Clinical science; genetic analysis; interaction of cytochrome P450 enzymes affected in CAH; development of a gonad-specific POR knock-out mouse.
Professor G Landini
Dentistry; applied fractal principles to study morphological complexity; image segmentation; quantitative measurement and focusing.
Dr R May
Biosciences; evolution and molecular basis of host-pathogen interactions.
Dr P Mendes
Chemistry; nanoscience and nanotechnology; biomimetic materials for studies of cell behaviour; applications in medical imaging and catalysis.
Dr F Mueller
Reproduction, genes and development; molecular mechanisms of transcription regulation in the vertebrate embryo; comparative and functional genomic tools to address the interaction specificity of transcription factors.
Dr E Odintsova
Cancer sciences; tetraspanins and receptor signalling.
Professor M Overduin
Cancer studies and biomolecular NMR; FYVE domains; phox homology; tetraspanin signaling; SHD1 adaptation; GTPase signaling; SH2 domains.
Dr T Overton
Biochemical engineering; microbial physiology and gene regulation in bioprocesses.
Dr A Peacock
Bioinorganic chemistry; medicinal chemistry; metallodrugs; de novo peptide design; chemical biology.
Professor J Preece
Supramolecular chemistry; nanoscale materials science for (i) electron beam resists; (ii) assembly of inorganic/ organic hybrid nanoparticles with novel electro-optic, structural and medicinal properties (gene delivery); (iii) liquid crystals; (iv) surfaces used in technological applications.
Dr G E Rainger
Dr J Renshaw
Earth and environmental sciences; microbial transformations of radionuclides and metals; biogeochemistry of metals and organic pollutants in groundwater.
Dr J Rowe
Evolutionary computation; multi-agent systems; artificial life and other complex adaptive systems.
Dr R Shelton
Dentistry; tissue-engineering approaches for bone and oral mucosal replacement; influence of plasma proteins on setting characteristics of mineral trioxide.
Dr P Sloan
Dr P Tino
Artificial intelligence; machine learning; neural networks; evolutionary computation; bioinformatics; computational biology; intelligent methods for pattern recognition; molecular biology, computational models of dynamical systems.
Dr C Tselepis
Cancer sciences; structural biology and biomarkers; cancer and chronic disease epidemiology; gastrointestinal disease and medical decision-making.
Dr J Tucker
Chemistry; synthesis of tagged DNA (fluorescent and redox labels); sensors for nucleobase variations (SNPs) and base modifications; switchable binding systems.
Dr D Ward
Cancer sciences; structural biology and biomarkers.
Dr M Ward
Mechanical engineering; bio-medical & micro-engineering.
Dr J Wilkie
Computational bio-organic chemistry with applications in biomedical visualisation and experimental interpretation.
Dr G Worth
Non-adiabatic effects in photochemistry; quantum dynamics using the MCTDH algorithm; controlling chemistry using laser fields.
Prof X Yao
Computer science/CERCIA; evolutionary computation; neural network ensembles; complex adaptive systems.