PhD Title: Tetraspanin regulation of ADAM10: impact on atherosclerosis
Supervisors: Dr Michael G Tomlinson (School of Biosciences) and Professor G Ed Rainger (School of Clinical and Experimental Medicine)
Atherosclerosis is a chronic disease that occurs within the wall of arteries and is ultimately a major cause of death and disability from heart attack and stroke. ADAM10 is a transmembrane metalloprotease that is upregulated on endothelial cells during atherosclerosis and promotes leukocyte transmigration in vivo. However, the effects of endothelial ADAM10 on leukocyte transmigration and atherosclerosis are largely unknown. The aim of my research is to determine whether endothelial ADAM10 promotes leukocyte transmigration and atherosclerosis in vivo, and secondly whether certain tetrapsanins help ADAM10 to achieve this unwanted outcome.