Understanding estrogen receptor transcription in breast cancer
Dr Jason Carroll
Cancer Research UK, University of Cambridge
Dr Carrolls' lab is interested in understanding how the Estrogen Receptor (ER) causes gene transcription and how this contributes to breast cancer progression. His lab is also interested in understanding how breast cancer therapies work and what happens if they fail. They predominately do this using molecular, genomic and proteomic approaches and have pioneered ChIP-seq approaches using human core biopsies.
Jason has published some excellent papers defining novel ER associated factors. This includes a seminal paper describing FoxA1 as a pioneering factor for ER alpha driven gene activation (Nature Genetics 2010) and the mechanism by which differential ER-binding programmes in patients with a poor prognosis occurs contributes to disease (Nature 2012).
It's going to be an excellent talk so please make a note in your diary and come along!