BRCA1: New roles in mRNA splicing and tissue specific tumourigenesis
Dr. Kienan Savage, Centre for Cancer Research and Cell Biology, Queen's University Belfast
Kienan Savage was appointed to the position of Cancer Focus Northern Ireland Lecturer in Molecular Oncology in November 2012. Kienan originally completed his Bachelor of Biomedical Science at Griffith University, in Queensland Australia. He followed this with a joint MBBS/PhD programme at the University of Queensland and the Queensland Institute of Medical Research, where he carried out his PhD studies in the lab of Prof. Kum Kum Khanna.
Kienan’s PhD focused on the involvement of DNA damage response and repair proteins in the development and progression of breast cancer during which he demonstrated the involvement of the BRCA1 protein in the G1/S checkpoint, characterised the role of KAP-1 phosphorylation in chromatin remodeling and DNA repair and helped with the discovery of the novel DNA repair protein hSSB1. Following his PhD in 2007 Kienan joined Prof. Paul Harkin’s group as a post-doc where his work focused on identifying and characterizing novel proteins that co-operate with BRCA1 in the cellular DNA damage response.
Kienan’s current work focuses on understanding the novel role of the mRNA splicing machinery in the cellular DNA damage response and how mutations in these proteins affect cancer development progression and response to treatment.