Causes of chromosomal instability in Cancer
Dr Sarah McClelland, Barts Cancer Institute, London
Dr Sarah McClelland’s talk should interest anyone who is interested in genomic instability, replication stress or tumour heterogeneity.
Sarah obtained her PhD in Biochemistry at the University of Bristol, followed by postdoctoral fellowships working on DNA damage and cell cycle at SUNY, Marie Curie Research Institute Surrey, and the lab of Charles Swanton at the CRUK LRI. She started her own group at the Barts Cancer Institute, London in 2013.
Burrell RA*, McClelland SE*, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N, Dewhurst SM, Gronroos E, Chew SK, Rowan AJ, Schenk A, Sheffer M, Howell M, Kschischo M, Behrens A, Helleday T, Bartek J, Tomlinson IP, Swanton C. Replication stress links structural and numerical chromosomal instability in colorectal cancer. Nature. 2013 Feb 28, 494:492-6. PMID: 23446422
Birkbak NJ, Eklund AC, Li Q, McClelland SE, Endesfelder D, Tan P, Tan IB, Richardson AL, Szallasi Z, Swanton C. Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer. Cancer Res., 2011. PMID: 21270108
McClelland SE*, Borusu S*, Amaro AC, Winter JR, Belwal M, McAinsh AD & Meraldi P. The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity. EMBO J., 2007. PMID: 18007590
Porter IM, McClelland SE, Khoudoli GA, Hunter CJ, Andersen JS, McAinsh AD, Blow J & Swedlow, J.R. Bod1, a novel kinetochore protein required for chromosome biorientation. J. Cell Biol., 2007. PMID: 17938248
- Mechanisms driving chromosomal instability in Ovarian cancer
- Investigating the function of genes overexpressed in cancer in maintenance of genome stability- Investigating the function of genes overexpressed in cancer in maintenance of genome stability
- Understanding the relationship between replication stress and chromosomal instability
There will be opportunity to speak with Sarah on Tuesday afternoon; please email firstname.lastname@example.org if you're interested.