Constanze Bonifer studied Biology at the University of Cologne, Germany and graduated 1980 with a first class degree in Biochemistry, Chemistry and Genetics. She then went on to do a PhD in Biochemistry and Molecular Biology, first at the University of Cologne, then at the Centre for Molecular Biology, University of Heidelberg.
This was followed by Postdoctoral training periods at the Karolinska Institute, Stockholm, and the National Institute for Medical Research in London where she started to work on gene regulation.
1990 she became Assistant Professor and independent group leader at University of Freiburg, Germany, where she worked on gene regulation in the hematopoietic system.
1997 she went back to the UK and became a group leader at the Molecular Medicine Unit, University of Leeds, where she started to work not only on basic mechanisms controlling blood cell development, but also on epigenetic mechanisms controlling leukemogenesis.
She became a Reader in 2000, a Professor in 2003 and in 2004 became a full Professor and Chair of Experimental Haematology. In 2006 she was appointed Head of Section of Expeirmental Haematology at the Leeds Institute of Molecular Medicine.
Since August 2011, Constanze is in Birmingham as Chair of Experimental Haematology at the Institute of Biomedical Research.
Leddin, M., Perrod, C. , Hoogenkamp, M., Ghani, S., Ass, S., Heinz,S., Wilson, N.K., Follows, G., Schönheit,J., Vockentanz,L., Mosamam,A., Chen, W., Tenen, D.G., Westhead, D.R., Göttgens, B., Bonifer, C*. and Rosenbauer, F*. (2011) (*joint corr. authors). Two distinct auto-regulatory loops operate at the Pu.1 locus in B cells and myeloid cells. Blood 117(10):2827-38
Lamprecht, B., Walter, K., Kreher, S., Kumar, R., Hummel, M., Lenze, D., Köchert, K., Bouhlel, M.A., Richter, J., Soler, E., Stadhouders, R., Jöhrens, C., Wurster, K.D., Callen, C., Harte, M.F., Giefing, M., Barlow, R., Stein, H., Anagnostopoulos, I., Janz, M., Cockerill, P.N., Siebert, R., Dörken, B., Bonifer, C.*, and Mathas, S.* (2010). (*Joint corresponding authors). De–repression of an endogenous long terminal repeat activates the CSF1R proto–oncogene in human lymphoma. Nature Medicine. 16, 571 – 579
Hoogenkamp, H.; Lichtinger, M.; Krysinska, H.; Lancrin, C.; Clarke, D.; Williamson, A.; Mazzarella,L.; Ingram, R.; H. Jorgensen, A. Fisher, D,G. Tenen, Kouskoff, V.; G.Lacaud, and C.Bonifer (2009). Early chromatin unfolding by Runx1 - a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program. Blood 114; 299-309.
Barton, J.L.; Bunka, D.H.J.; Knowling, S.E., Lefevre, P., Warren, A.l, Bonifer, C. and Stockley, P.G. (2009). Isolation and characterization of RNA-aptamers that disrupt the binding of the RUNX1-CBF complex to DNA. Nucleic Acids Res. 37, 6818 - 6830
Lefevre, P., Lacroix, C., Witham, J.,Cockerill, P.N. and Bonifer, C (2008). The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and non-coding RNA transcription. Molecular Cell 32, 129 – 139
Ebralidze, A., Guibal, Steidel, U., Zhang, P., Lee, S., Rosenbauer, F., Huang, G., Petkova, V., Dayaram, T., Klupp, J., Hoogenkamp, M., Bonifer, C.*, Tenen, D.G.* (.* joint last authors ). 2008. PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element. Genes & Development. 22, 2085-2092
M.Hoogenkamp, A. Krysinska, R.Ingram, G. Huang, R. Barlow, D. Clarke, A. Ebralidze, P. Zhang, H. Tagoh, P. Cockerill, D.G.Tenen and C.Bonifer. (2007). The Pu.1 locus is differentially regulated at the level of chromatin structure and non-coding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis. Mol. Cell. Biol. 27, 7425 – 7438
Krysinska, H., Hoogenkamp, M., Ingram, R., Wilson, N., Tagoh, H., Laslo, P., Singh, H. and Bonifer, C. (2007). A two-step, PU.1 dependent, mechanism for developmentally regulated chromatin remodelling and transcription of the c-fms gene. Mol. Cell. Biol.: 27:878-87