Hughes CE, Sinha U, Pandey A, Eble JA, O'Callaghan CA, Watson SP (2013) .Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2). J Biol Chem. 2013 Feb 15;288(7):5127-35. doi: 10.1074/jbc.M112.411462. Epub 2012 Dec 21.
Manne BK, Getz TM, Hughes CE, Alshehri O, Dangelmaier C, Naik UP, Watson SP, Kunapuli SP. (2013) Fucoidan Is a Novel Platelet Agonist for the C-type Lectin-like Receptor 2 (CLEC-2). J Biol Chem. 2013 Mar 15;288(11):7717-26. doi: 10.1074/jbc.M112.424473. Epub 2013 Jan 22.
Hughes CE, Radhakrishnan UP, Lordkipanidzé M, Egginton S, Dijkstra JM, Jagadeeswaran P,Watson SP (2012) G6f-like is an ITAM-containing collagen receptor in thrombocytes.PLoS One. 2012;7(12):e52622. doi: 10.1371/journal.pone.0052622. Epub 2012 Dec 21.
Finney BA, Schweighoffer E, Navarro-Núñez L, Bénézech C, Barone F, Hughes CE, Langan SA, Lowe KL, Pollitt AY, Mourao-Sa D, Sheardown S, Nash GB, Smithers N, Reis e Sousa C, Tybulewicz VL, Watson SP.(2012) CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood. 2012 Feb 16;119(7):1747-56. doi: 10.1182/blood-2011-09-380709. Epub 2011 Dec 20.
Jarvis GE, Bihan D, Hamaia S, Pugh N, Ghevaert CJ, Pearce AC, Hughes CE, Watson SP, Ware J, Rudd CE, Farndale RW. (2012) A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1). J Thromb Haemost. 2012 Feb;10(2):268-77. doi: 10.1111/j.1538-7836.2011.04567.x.
Brazón J, Hughes CE, Mori J, Sevcik C, D'suze G, Watson SP. (2011) Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway. Platelets. 2011;22(3):165-72. doi: 10.3109/09537104.2010.544343. Epub 2011 Feb 15.
Hughes CE, Navarro-Núñez L, Finney BA, Mourão-Sá D, Pollitt AY, Watson SP; (2010) CLEC-2 is not required for platelet aggregation at arteriolar shear. JTH; 8(10) 2328-32
Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O’Callaghan CA, Fütterer K, Watson SP; (2010) CLEC-2 activates Syk through dimerisation. Blood; 115(14) 2947-55
Spalton JC, Mori J, Pollitt AY, Hughes CE, Eble JA, Watson SP; (2009) The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signalling in platelets. JTH; 7(7) 1192-9
Grygielska B, Hughes CE, Watson SP ; (2009) Molecular basis of platelet activation by an aIIbb3-CHAMPS peptide. JTH; 7(2) 339-46
Pears C, Thornber K, Auger JM, Hughes CE, Grygielska B, Pearce AC, Watson SP; (2008) Differential roles of the PKC novel isoforms, PKCd and PKCe, in mouse and human platelets. PLoS ONE; 3(11) e3793
Hughes CE, Auger JM, McGlade J, Eble JA, Pearce AC, Watson SP; (2008) Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2. JTH; 6(12) 2152-59
Riba R, Hughes CE, Graham A, Watson SP, Naseem KM; (2008) Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex. JTH; 6(6) 1012-20
Hughan S, Hughes CE, McCarty OJ, Schweighoffer E, Tybulewicz V, Watson SP; (2007) GPVI-potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk. ATVB; 27(2) 422-2