Dr Zaki Hassan-Smith MBBS, BMedSci(Hons), MRCP

Clinical Lecturer

Endocrinology, Diabetes and Metabolism


Contact details

Telephone 0121 415 8811

Fax 0121 415 8712

Email z.hassansmith@bham.ac.uk

School of Clinical and Experimental Medicine
College of Medical and Dental Sciences
University of Birmingham
B15 2TT


Zaki Hassan-Smith is a Clinical Lecturer and Honorary Specialist Registrar in Endocrinology. His clinical interests are in Pituitary and Adrenal disease. His research interests, developed under supervision of Prof Paul Stewart, centre around the long-term effects of glucocorticoids in ageing and disease. He was awarded the Society for Endocrinology Young Endocrinologist prize for top scoring oral communication at the British Endocrine Society Meeting in 2013. Prior to his current European Research Council funded post, he was an NIHR Academic Clinical Fellow and Specialty Registrar at UHB. He completed his Senior House Officer rotation at St Bartholomew’s and the Royal London Hospitals where he obtained his MRCP. He was House Officer in the Dept of Endocrinology at St. Bart’s and he completed an intercalated BMedSci project under the Supervision of Profs Marta Korbonits and Ashley Grossman.


  • Member of the Royal College of Physicians (MRCP)
  • MBBS
  • BMedSci(Hons)
  • Medical Education Post-Graduate Award


Dr Hassan-Smith completed a Medical Education Post-Graduate Award at Warwick University in 2009, and has taken an active interest in teaching in the following areas at the University of Birmingham:

  • SGT Adrenal, Reproductive, Pituitary, Calcium/Bone Modules MBChB
  • Endocrinology of Ageing Lecture BMedSci
  • Glucocorticoid metabolizing enzymes and skeletal ageing BClinSci Lecture 
  • Supervisor SSM 4th Year MBChB students: Use of Corticosteroids


Featured Research Projects

1. PhD Thesis: Glucocorticoids, 11ß-HSD1, and the Aged Phenotype, 2010-13.
2. Long-term Outcomes of Cushing’s Disease treated with Trans-Sphenoidal Surgery 2009-2012.
3. Urine Steroid Metabolomics and Sub-Clinical Cushing’s Syndrome, 2012-13.
4. Adrenal Insufficiency (Treatment, Adverse Outcomes and Patient Education) Study, UHB NHS FT.
5. Cardiac Function with Dopamine Agonist Therapy for Prolactinomas, UHB NHS FT.
6. mCPP and Appetite Study. Medical co-investigator, 2011-2013.
7. Life-threatening complications of thyroidectomy study, 2005.
8. Ghrelin receptor gene polymorphisms and body size, 2003-8.
9. Polymorphisms in the GHRH receptor and body size study, 2003-4.

Pharmaceutical Research Projects

1. European Adrenal Insufficiency Registry (EU-AIR). Site Investigator UHB NHS FT, 2012-13.
2. OSI-906 a Novel Treatment for Adrenocortical carcinoma. Site Investigator 2010.

Other activities

Honorary SpR at UHB

‘You and Your Hormones’ SfE Public Information Website – Contributor/Peer Reviewer 2012-Present

Organiser of UHB Endocrine Clinical Cases Meetings 2011-2013


11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. Tiganescu A, Tahrani AA, Morgan SA, Otranto M, Desmoulière A, Abrahams L, Hassan-Smith Z, Walker EA, Rabbitt EH, Cooper MS, Amrein K, Lavery GG, Stewart PM. J Clin Invest. 2013 Jul 1;123(7):3051-60. doi: 10.1172/JCI64162. Epub 2013 Jun 3.

Regulation of Lipid Metabolism by Glucocorticoids and 11β-HSD1 in Skeletal Muscle. Morgan SA, Gathercole LL, Simonet C, Hassan-Smith ZK, Bujalska I, Guest P, Abrahams L, Smith DM, Stewart PM, Lavery GG, Tomlinson JW. Endocrinology. 2013 Jul;154(7):2374-84. doi: 10.1210/en.2012-2214. Epub 2013 Apr 30. PMID: 23633532 [PubMed - in process]

Outcome of Cushing’s disease following transphenoidal surgery in a single center over 20 years. Hassan-Smith ZK, Sherlock M, Reulen RC, Arlt W, Ayuk J, Toogood AA, Cooper MS, Johnson AP, Stewart PM. J Clin Endocrinol Metab. 2012 Apr;97(4):1194-201. Epub 2012 Jan 25.

Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells. Ahasan MM, Hardy R, Jones C, Kaur K, Nanus D, Juarez M, Morgan SA, Hassan-Smith Z, Bénézech C, Caamaño JH, Hewison M, Lavery G, Rabbitt EH, Clark AR, Filer A, Buckley CD, Raza K, Stewart PM, Cooper MS. Arthritis Rheum. 2012 Jul;64(7):2404-13. doi: 10.1002/art.34414.

Overview of the endocrine response to critical illness: how to measure it and when to treat. Hassan-Smith Z, Cooper MS. Best Pract Res Clin Endocrinol Metab. 2011 Oct;25(5):705-17. Review.

Inherited forms of mineralocorticoid hypertension. Hassan-Smith Z, Stewart PM. Curr Opin Endocrinol Diabetes Obes. 2011 Jun;18(3):177-85. Review.

A UK-Wide Survey of Life-threatening Thyroidectomy Complications. Hassan-Smith ZK, Gopinath P, Mihaimeed F. J Thyroid Res. 2011 Feb 10;2011:329620.. 2011 Feb 10;2011:329620.

Ghrelin receptor gene polymorphisms and body size in children and adults. Garcia EA, Heude B, Petry CJ, Gueorguiev M, Hassan-Smith ZK, Spanou A, Ring SM, Dunger DB, Wareham N, Sandhu MS, Ong KK, Korbonits M. J Clin Endocrinol Metab. 2008 Oct;93(10):4158-61. Epub 2008 Jul 22.

Book Chapters

Endocrine Myopathies. Hassan-Smith ZK, Douglas MD, Ruff RL (Book Chapter) Neuromuscular disorders in clinical practice. Edited by Katirji B, Kaminski HJ, Ruff RL. 2nd Edition (Springer) Release date May 31, 2013.

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