Dr Clara Yates

Research Fellow

Cardiovascular and Respiratory Sciences

Contact details

School of Clinical and Experimental Medicine
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
B15 2TT

About

As part of Professor Gerard Nash’s group, Clara is interested in leukocyte recruitment to endothelial cells during inflammation. Clara’s current research concerns microvesicles (MV), sub-micron particles released from cells and Clara is particularly interested in those released from platelets, leukocytes and endothelial cells. As part of the NIHR Surgical Reconstruction and Microbiology Research Centre. Clara’s current research is focused on analysing MV in trauma patients. Using in vitro flow based adhesion assays Clara is investigating the effect of MV from patients on endothelial cell inflammatory responses.

Qualifications

BSc (Hons), University of East Anglia, 2004

PhD, Medical Science, University of Birmingham, 200

Biography

Clara completed her undergraduate degree in Biomedicine at the University of East Anglia where she developed an interest in chronic inflammatory diseases, particularly atherosclerosis. She then completed a PhD at the University of Birmingham in 2009 which investigated the ability of omega-3 polyunsaturated fatty acids to modulate endothelial cell function. Clara has continued post-doctoral training in Birmingham investigating endothelial cell activation by monocytes and monocyte subsets in the context of atherosclerosis, using complex co-culture models.

Clara is on the Postdoctoral / Early Researcher Career Development And Training (PERCAT) committee as joint post-doctoral representative for the School of Clinical and Experimental Medicine. PERCAT aims to facilitate and support career development and runs a number of programmes and events including a research gala, monthly masterclasses and a seminar series. In addition Clara jointly co-ordinates ‘meet the speaker’ sessions for the Cardiovascular seminar series.

Clara is also involved with the University’s widening participation schemes, Access to Birmingham (A2B) and Realising Opportunities (ROP) and since 2011 has tutored 30 students applying for courses in the College of Medical and Dental Sciences.

Teaching

  • MBChB
  • BMedSc (Biomaterials) BSc
  • BMedSc BSc

Publications

Yates CM, McGettrick HM, Rainger GE. Adhesion of tumour cells to matrices and endothelium. Methods in Molecular Medicine. (2013). In press.

Ahmed SR, McGettrick HM, Yates CM, Buckley CD, Ratcliffe J, Nash GB, Rainger GE. Prostaglandin-D2 regulates CD4+ memory T cell trafficking across blood vascular endothelium and primes these cells for clearance across lymphatic endothelium. The Journal of Immunology. 2011;187:1432-1439

Yates CM, Calder PC, Rainger GE. N-3 PUFAs and cardiovascular disease. British Society for Cardiovascular Research Bulletin. 2011;24:4-9

Yates CM, Abdelhamid M, Adam DJ, Nash GB, Bradbury AW, Rainger GE. Endovascular aneurysm repair reverses the increased titre and the inflammatory activity of interleukin-1α in the serum of patients with abdominal aortic aneurysm. The Journal of Vascular Surgery. 2011;54:497-503

Yates CM, Tull SP, Madden J, Calder PC, Grimble RF, Nash GB, Rainger GE. The n-3-polyunsaturated fatty acid DHA inhibits the adhesion of flowing neutrophils to cytokine stimulated endothelial cells. The Journal of Nutrition. 2011;141:1331-1134

Yates CM, Kuckleburg CJ, Kalia N, Zhao Y, Nash GB, Watson SP, Rainger GE. Endothelial cell-borne platelet bridges selectively recruit monocytes in human and mouse models of vascular inflammation. Cardiovascular Research. 2011;91:134-141. * joint authorship

Yates CM, Tull SP, Maskrey BH, O’Donnell VB, Madden J, Grimble RF, Calder PC, Nash GB, Rainger GE. Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. PLoS Biology 2009 Aug;7(8):e1000177. * joint authorship

Harrison M, Abu-Elmagd M, Grocott T, Yates C, Gavrilovic J, Wheeler GN. Matrix metalloproteinase genes in Xenopus development. Developmental Dynamics. 2004;231:214-22

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