Professor Gregory YH Lip MD, FRCP (London, Edinburgh, Glasgow), DFM, FACC, FESC

Consultant Cardiologist & Professor of Cardiovascular Medicine, Director - Haemostasis Thrombosis & Vascular Biology Unit

Cardiovascular and Respiratory Sciences

Contact details

Telephone +44 (0) 121 5075080

Fax +44 (0) 121 554 4083

Email g.y.h.lip@bham.ac.uk

University of Birmingham Centre for Cardiovascular Sciences
City Hospital
Birmingham
B187QH

About

Professor Lip, MD, is an academic clinical cardiologist based in a busy city centre teaching hospital and leads a large, multidisciplinary research group (including clinical and laboratory-based components). He is also Visiting Professor of Haemostasis Thrombosis and Vascular Sciences in the School of Life & Health Sciences at the University of Aston in Birmingham, England.

Half of his time is spent as a clinician, and he practises the full range of cardiovascular medicine, including outpatient clinics, with large atrial fibrillation and hypertension specialist clinics, and coronary care units. He also undertakes coronary intervention and assists in a 24/7 primary angioplasty rota for ST elevation MIs.

As an academic, Professor Lip provides strategy and research direction for his group, with many local, national, and international collaborations in progress. He has had a major interest into the epidemiology of AF, as well as the pathophysiology of thromboembolism in this arrhythmia.  Furthermore, he has been researching stroke and bleeding risk factors, and improvements in clinical risk stratification.  The CHA2DS2-VASc and HAS-BLED scores for assessing stroke and bleeding risk, respectively – were first proposed and independently validated following his research, and are now incorporated into major international management guidelines.

Qualifications

  • Fellow of the Royal College of Physicians of London (F.R.C.P.Lond) May 2001
  • Fellow of the Royal College of Physicians and Surgeons of Glasgow (F.R.C.P.Glasg) 1999
  • Fellow of the Royal College of Physicians of Edinburgh (F.R.C.P.Edin) Sept 1998
  • Fellow of the European Society of Cardiology (F.E.S.C.) June 1997
  • Fellow of the American College of Cardiology (F.A.C.C.) August 1996
  • Doctor of Medicine (M.D.) University of Glasgow, September 1994
  • Diploma of Forensic Medicine (DFM) with Class Prize. September 1993
  • Membership of the Royal Colleges of Physicians M.R.C.P.(U.K.) March 1991
  • July 1988   M.B., Ch.B. (with commendation) University of Glasgow

Biography

Professor Lip is a member of the European Heart Rhythm Association (EHRA) and its scientific documents committee and serves on the board of the Working Group on Hypertension of the Heart of the European Society of Cardiology (ESC). He is a member of the Working Groups of Thrombosis and Cardiovascular Pharmacology of the ESC. He is also a member of the European Association of Percutaneous Coronary Revascularisation.

Professor Lip has acted as Clinical Adviser for the UK National Institute for Health & Clinical Excellence (NICE) guidelines on atrial fibrillation (AF) management. He was on the writing committee for the 8th American College of Chest Physicians (ACCP) Antithrombotic Therapy Guidelines for Atrial Fibrillation, as well as various guidelines and/or position statements from EHRA including the EHRA statement on defining endpoints for AF management and EHRA guidelines for antithrombotic therapy during ablation. He has acted as peer reviewer for recent ESC guidelines. He is currently chairing an ongoing ESC task force, writing a EHRA/Working Group of Thrombosis Position Statement on Bleeding Risks in Atrial Fibrillation Patients (due 2012). He is also on the writing committee of the 2010 ESC Guidelines on Atrial Fibrillation, the new ESC Guidelines on Heart Failure (due 2011) and is Deputy Editor (“content expert”) for the 9th ACCP guidelines on antithrombotic therapy for AF.

Professor Lip has acted as Senior Editor for major international textbooks [eg, Lip GYH, Hall JE (eds) Comprehensive Hypertension. Mosby 2007] and Section Editor on hypertension (eg, Crawford, DiMarco, Paulus Cardiology, now in 3rd edition), as well as contributed to major textbooks [eg, the European Textbook of Cardiovascular Medicine (chapter on atrial fibrillation that serves as the core curriculum for ESC cardiology trainees), and Crawford’s Cardiology textbook chapter on atrial fibrillation, etc.

Professor Lip is involved at the senior editorial level for major international journals, including the Journal of Human Hypertension (Editor-in-Chief); Thrombosis & Haemostasis (Editor-in-Chief, Clinical Studies); Europace (Associate Editor); and Circulation (Guest Editor).

Research

Professor GYH Lip MD FRCP FACC FESC has research interests in atrial fibrillation, hypertension, heart failure, thrombosis and antithrombotic therapy, and ethnic differences in vascular disease. In addition, he has a major interest into the psychophysiology and understanding of the disease process in cardiovascular disease (including atrial fibrillation), as well as physician and patient perceptions of antithrombotic management strategies. Finally, he leads a laboratory-based research group into thrombosis and vascular biology in cardiovascular disease and stroke.

Other activities

Professor Lip has served on many clinical trial steering committees – being involved in study design, organisation and conduct - as well as trial Data Safety Monitoring Boards. He is currently the lead for the cardiovascular research programme for Sandwell and West Birmingham NHS Hospitals NHS Trust, as well as Clinical Lead for the Birmingham and Black Country Cardiovascular Clinical Comprehensive Local Research Network. 

Professor Lip has a national and international profile in atrial fibrillation, thrombosis and antithrombotic therapy.

Publications

1540+ citations on Medline, a selection are as follows:

Friberg L, Benson L, Rosenqvist M, Lip GY. Assessment of female sex as a risk factor in atrial fibrillation in Sweden: nationwide retrospective cohort study. BMJ. 2012 May 30;344:e3522.

Rasmussen LH, Larsen TB, Graungaard T, Skjøth F, Lip GY. Primary and secondary prevention with new oral anticoagulant drugs for stroke prevention in atrial fibrillation: indirect comparison analysis. BMJ. 2012 Nov 5;345:e7097. doi:10.1136/bmj.e7097.

Friberg L, Rosenqvist M, Lip GY. Net clinical benefit of warfarin in patients  with atrial fibrillation: a report from the Swedish atrial fibrillation cohort study. Circulation. 2012 May 15;125(19):2298-307. Epub 2012 Apr 18. 

Friberg L, Rosenqvist M, Lip GY. Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study. Eur Heart J. 2012 Jun;33(12):1500-10.

Apotolakis S, Lane D, Gao Y, Buller H, Lip GY.  Performance of the HEMORR2HAGES, ATRIA and HAS-BLED bleeding risk prediction scores in anticoagulated patients with atrial fibrillation: The AMADEUS study.  J Am Coll Cardiol 2012;60:861-7

Lip GY, Larsen TB, Skjøth F, Rasmussen LH. Indirect Comparisons of New Oral Anticoagulant Drugs for Efficacy and Safety When Used for Stroke Prevention in Atrial Fibrillation. J Am Coll Cardiol. 2012;60:738-46

Lip GY, Frison L, Halperin JL, Lane DA. Comparative validation of a novel ris score for predicting bleeding risk in anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension, Abnormal Renal/Liver Function, Stroke,  Bleeding History or Predisposition, Labile INR, Elderly, Drugs/Alcohol Concomitantly) score. J Am Coll Cardiol. 2011 Jan 11;57(2):173-80.

Boriani G, Botto GL, Padeletti L, Santini M, Capucci A, Gulizia M, Ricci R, Biffi M, De Santo T, Corbucci G, Lip GY; Italian AT-500 Registry Investigators. Improving stroke risk stratification using the CHADS2 and CHA2DS2-VASc risk scores in patients with paroxysmal atrial fibrillation by continuous arrhythmia burden monitoring. Stroke. 2011 Jun;42(6):1768-70.

Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest. 2010 Nov;138(5):1093-100.

Olesen J, Lip GY, Kamper AL, Hommel K, Kober L, Lane DA, Lindhardsen J, Gislason GH, Torp-Pedersen C.  Stroke and Bleeding in Atrial Fibrillation with Chronic Kidney Disease. N Engl J Med 2012;367:625-35.

Olesen JB, Lip GY, Hansen ML, Hansen PR, Tolstrup JS, Lindhardsen J, Selmer C, Ahlehoff O, Olsen AM, Gislason GH, Torp-Pedersen C. Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study. BMJ. 2011 Jan 31;342:d124. doi: 10.1136/bmj.d124. PubMed PMID: 21282258

Reviews

Lip GY, Tse HF, Lane DA.  Seminar – Management of atrial fibrillation.  Lancet 2012;379(9816):648-61

Banerjee A, Marín F, Lip GY. A new landscape for stroke prevention in atrial fibrillation: focus on new anticoagulants, antiarrhythmic drugs, and devices. Stroke. 2011 Nov;42(11):3316-22.

Marinigh R, Lane DA, Lip GY. Severe renal impairment and stroke prevention in atrial fibrillation: implications for thromboprophylaxis and bleeding risk. J Am  Coll Cardiol. 2011 Mar 22;57(12):1339-48.

Marinigh R, Lip GY, Fiotti N, Giansante C, Lane DA. Age as a risk factor for stroke in atrial fibrillation patients implications for thromboprophylaxis: Implications for thromboprophylaxis.  J Am Coll Cardiol. 2010 Sep 7;56(11):827-37.

Guidelines and Consensus Documents

Lip GY, Ponikowski P, Andreotti F, Anker SD, Filippatos G, Homma S, Morais J,  Pullicino P, Rasmussen LH, Marin F, Lane DA. Thrombo-embolism and antithrombotic therapy for heart failure in sinus rhythm. A Joint Consensus Document from the ESC Heart Failure Association and the ESC Working Group on Thrombosis.  Eur J Heart Fail. 2012 May 19. [Epub ahead of print] PubMed PMID: 22611046.

You JJ, Singer DE, Howard PA, Lane DA, Eckman MH, Fang MC, Hylek EM, Schulman S, Go AS, Hughes M, Spencer FA, Manning WJ, Halperin JL, Lip GY; American College of Chest Physicians. Antithrombotic therapy for atrial fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e531S-75S.

Lip GY, Andreotti F, Fauchier L, Huber K, Hylek E, Knight E, Lane D, Levi M, Marín F, Palareti G, Kirchhof P. Bleeding risk assessment and management in atrial fibrillation patients. Executive Summary of a Position Document from the European Heart Rhythm Association [EHRA], endorsed by the European Society of Cardiology [ESC] Working Group on Thrombosis. Thromb Haemost. 2011 Nov 30;106(6):997-1011.

Lip GY, Huber K, Andreotti F, Arnesen H, Airaksinen JK, Cuisset T, Kirchhof P, Marín F; Consensus Document of European Society of Cardiology Working Group on Thrombosis. Antithrombotic management of atrial fibrillation patients presenting  with acute coronary syndrome and/or undergoing coronary stenting: executive summary--a Consensus Document of the European Society of Cardiology Working Group on Thrombosis, endorsed by the European Heart Rhythm Association (EHRA) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 2010 Jun;31(11):1311-8.

Camm AJ, Lip GY, De Caterina R, Savelieva I, Atar  D, Hohnloser SH, Hindricks G, Kirchhof P. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: An update of the 2010 ESC Guidelines for the management of atrial fibrillation * Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J. 2012 Nov;33(21):2719-47.

Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S, Van Gelder IC, Al-Attar N, Hindricks G, Prendergast B, Heidbuchel H, Alfieri O, Angelini A, Atar D, Colonna P, De Caterina R, De Sutter J, Goette A, Gorenek B, Heldal M, Hohloser SH, Kolh P, Le Heuzey JY, Ponikowski P, Rutten FH. Guidelines  for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J. 2010 Oct;31(19):2369-429.

Singer DE, Albers GW, Dalen JE, Fang MC, Go AS, Halperin JL, Lip GY, Manning WJ; American College of Chest Physicians. Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008 Jun;133(6 Suppl):546S-592S.

Back to top