Dr Zhangjie Su

Clinical Research Fellow

Neurobiology

Image of Dr Zhangjie Su

Contact details

NIHR SRMRC
Office 4, Education Centre, Level 1
Queen Elizabeth Hospital Birmingham
Mindelsohn Way, Edgbaston
Birmingham, B15 2WB

About

Dr Zhangjie Su is a Clinical Research Fellow for neurotrauma/neurosurgery at the NIHR SRMRC, working under Mr Tony Belli.

He has a research interest in imaging investigations, such as functional MRI, MR spectroscopy and PET, their application in patients with acquired brain injury, and the correlations with patient outcomes.

His previous research work included behavioural and electrophysiological studies of traumatic brain injury, and neuroimaging studies on inflammatory responses in patients with neurodegenerative disorders (e.g. early dementia) or brain tumours.

Dr Su is also a qualified medical doctor with full GMC registration and a licence to practise in the UK, working towards his career goal as an academic neurosurgeon.

Qualifications

  • PhD Medicine, University of Manchester, 2012
  • Masters degree in Neurosurgery, Nankai University, 2008
  • Bachelors Degree in Clinical Medicine, Sun Yat-sen University, 2005

Biography

Dr Zhangjie Su graduated with Honours from the Medical College of Sun Yat-sen University in Guangzhou, China. He carried on with his postgraduate study at Nankai University School of Medicine in Tianjin. This also included one year of clinical training as a Senior House Officer in Neurosurgery, Neurology and Neuroradiology at Tianjin First Centre Hospital.

During the study, He developed a research interest in neurotrauma and investigated the effect of heat stress preconditioning on the cognitive outcomes of diffuse axonal injury using a rat model, which led to a Masters Degree in Neurosurgery and several publications in the field of traumatic brain injury.

He came to the UK in 2008 to study for his PhD at the University of Manchester, having been awarded full scholarships. He conducted clinical imaging studies to investigate neuroinflammatory responses (microglial activation and translocator protein expression) in patients with brain tumours (mainly gliomas). His work has been widely disseminated in national and international conferences. He was also involved in imaging studies on neuroinflammation in healthy volunteers and patients with other conditions, such as mild cognitive impairment and psoriasis.

Dr Su passed the PLAB exam for international medical graduates and gained full GMC registration with a licence to practise in the UK during his PhD study in 2011. After successfully obtaining a PhD degree in Medicine, he joined the University of Birmingham as a Clinical Research Fellow to work on neurotrauma projects in the Surgical Reconstruction and Microbiology Research Centre (SRMRC), National Institute for Health Research (NIHR).

Research

Current research focuses on acute responses, monitoring, management and outcome prediction of traumatic brain injury (TBI). Involved in clinical trails on TBI such as CRASH-3 (Tranexamic acid for the treatment of intracranial haemorrhage), RESCUEicp (cranietomy vs. medical management for elevated intracranial pressure), Golden Hour (early biomarkers for TBI), RECOS (repetitive sport concussions), and Spinal Core Injury trail.

Previous research included imaging and pathology studies of neuroinflammatory responses in gliomas and mild cognitive impairment; behavioural and electrophysiological studies of cognitive outcomes after diffuse axonal injury.

Other activities

  • Honorary Clinical Research Fellow in Neurosurgery, University Hospitals Birmingham NHS Foundation Trust
  • Honorary Research Fellow in Clinical Neurosciences, Institute of Brain, Behaviour and Mental Health, University of Manchester
  • Reviewer for Journal of Nuclear Medicine
  • Member of the European Society for Molecular Imaging

Publications

Su Z, Herholz K, Gerhard A, Roncaroli F, Du Plessis D, Jackson A, Turkheimer F and Hinz R (2013) [11C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches. European Journal of Nuclear Medicine and Molecular Imaging  40:1406-19

Su Z, Gerhard A, Hinz R et al (2012) In vivo imaging of translocator protein expression in human gliomas by PET with [11C]-(R)PK11195. Molecular Imaging and Biology 14 (suppl 2):s2087

Su Z, Gerhard A, Hinz R, et al (2012) In vivo imaging of translocator protein expression in gliomas by positron emission tomography (PET). Neuro-Oncology 14 (suppl 2): ii8

Su Z, Hinz R, Gerhard A, et al (2010) Preliminary evaluation of [11C]-(R)PK11195 kinetics in low-grade gliomas on the high resolution research tomograph. NeuroImage 52 (suppl 1):s151

Su Z, Han D, Sun B, Qiu J, Li Y, Li M, Zhang T and Yang Z (2009) Heat stress preconditioning improves cognitive outcome following diffuse axonal injury in rats. Journal of Neurotrauma 26:1695-706

Su Z, Han D, Zhang T, Chen BG and Yang Z (2008) Effect of Huishen Granule on cognitive outcome following diffuse axonal injury in rats. National Medical Journal of China 88:3003-7

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