Dr. Hofland’s translational research focuses on the regulatory mechanisms of steroid hormone production, with special emphasis on cancer. This has involved elucidating the role of circulating (ACTH, arginine-vasopressin) and local factors (activin, inhibin) on adrenocortical production of aldosterone, cortisol and androgens in health and diseases, such as adrenal hyperplasia, adenomas and cancer. The other main research theme comprises the study of intratumoral steroidogenesis in prostate cancer as a possible cause for castration resistance and disease progression. His interdisciplinary research has aimed to unravel the complex interplay between circulating adrenal androgens and intracrine androgen conversion. His current fellowship at CEDAM serves to investigate the contribution of a novel androgen synthesis pathway within prostate cancer cells to resistance to castration and second line hormonal treatments. This will be accomplished through a steroid metabolome analysis in translational models, giving a unique and complete insight into androgen metabolism in prostate cancer.
Hofland J, Steenbergen J, Hofland LJ, van Koetsveld PM, Eijken H, van Nederveen FH, Kazemier G, de Herder WW, Feelders RA and de Jong FH (2013) Protein kinase C-induced Activin A switches adrenocortical steroidogenesis to aldosterone by suppressing CYP17A1 expression. American Journal of Physiology – Endocrinology and Metabolism 305:E736-44
Hofland J, Delhanty PJ, Steenbergen J, Hofland LJ, van Koetsveld PM, van Nederveen FH, de Herder WW, Feelders RA and de Jong FH (2012) Melanocortin 2 receptor associated protein (MRAP) and MRAP2 in various human adrenocortical tissues: regulation of expression and association with ACTH responsiveness. Journal of Clinical Endocrinology and Metabolism 97(5):E747-54
Hofland J, van Weerden WM, Steenbergen J, Dits NF, Jenster G and de Jong FH (2012) Activin A stimulates AKR1C3 expression and growth in human prostate cancer. Endocrinology 153(12):5726-34
Hofland J, Feelders RA, van der Wal R, Kerstens MN, Haak HR, de Herder WW and de Jong FH (2011) Serum inhibin pro-αC is a tumor marker for adrenocortical carcinomas. European Journal of Endocrinology 166(2):281-9
Hofland J, van Weerden WM, Dits NF, Steenbergen J, van Leenders GJ, Jenster G, Schröder FH and de Jong FH (2010) Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer. Cancer Research 70(3):1256-64