Dr Meltem Weger

Marie Curie Research Fellow

Endocrinology, Diabetes and Metabolism

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Contact details

School of Clinical and Experimental Medicine
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

About

Meltem has received her PhD from the University of Heidelberg, Germany, and is currently working as a Marie-Curie Postdoctoral Research Fellow in the laboratory of Dr Nils Krone in the Centre for Endocrinology, Diabetes and Metabolism (CEDAM), School of Clinical and Experimental Medicine.

Her key research focus is the implementation of zebrafish as translational in vivo model for inborn errors of steroidogenesis and metabolic disorders. Furthermore, she is interested in the role of transcription factors involved in the development and regulation of the endocrine system.

Qualifications

  • 07/2013 PhD at the University of Heidelberg, Germany
  • 04/2009 Diploma in Biology at the University of Heidelberg, Germany

Research

Meltem has worked during her PhD studies at the Institute of Toxicology and Genetics at the Karlsruhe Institute of Technology, Germany. Here, she was interested in the understanding of the functional and developmental role of the bHLH transcription factors of the circadian clock and of energy metabolism using zebrafish as a model organism. Her work included the generation of transgenic zebrafish lines for monitoring glucocorticoid signalling and circadian core clock activity in vivo and in real time. Publications resulting from her work are listed below.

Publications

Research articles

Tixier V, Bataillé L, Etard C, Jagla T, Weger M, Da Ponte JP, Strähle U, Dickmeis T and Jagla K (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc Nat Acad Sci USA 110: 18982-7

Weger BD, Weger M, Jung N, Lederer C, Bräse S and Dickmeis T (2013) A chemical screening procedure for glucocorticoid signaling with a zebrafish larva luciferase reporter system. J Vis Exp 10.3791/50439

Weger M, Weger BD, Diotel N, Rastegar S, Hirota T, Kay SA, Strähle U and Dickmeis T (2013) Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Dev Biol 380: 259–273

Weger BD, Weger M, Nusser M, Brenner-Weiss G and Dickmeis T (2012) A chemical screening system for glucocorticoid stress hormone signaling in an intact organism. ACS Chem Biol 7: 1178–1183

Weger BD, Sahinbas M, Otto GW, Mracek P, Armant O, Dolle D, Lahiri K, Vallone D, Ettwiller L, Geisler R, Foulkes NS and Dickmeis T (2011) The light responsive transcriptome of the zebrafish. PLoS One 6:e17080

Reviews

Dickmeis T, Weger BD and Weger M (2013) The circadian clock and glucocorticoids – Interactions across many time scales. Mol Cell Endocrinol 380: 2-15

Dickmeis T, Sahinbas M and Weger BD (2009) Circadian Regulation of Physiology: Time for Glucocorticoids. Asia Pac J Endocrinol 1:75–86

Other

Weger M, Weger B and Dickmeis T. In vivo zebrafish luciferase assays–a practical guide. Protokoll kit.edu (http://goo.gl/WXf2QB)

Weger BD, Weger M and Dickmeis T (2012) Long term bioluminescence measurements for circadian clock monitoring. Application Note Perkin Elmer

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